Volume 22, Number 9—September 2016
Multidrug-Resistant Escherichia coli in Bovine Animals, Europe
|E. coli isolate||Year of isolation||Phylotype||ST||Plasmid size, kbp||PBRT†||Antimicrobial resistance profile||Antimicrobial resistance genotypes†||Colisitin MIC, mg/L|
|22134||2004||U||ST10||147; 57; 36||IncFIB, IncFIC, IncFII||AML, NAL, CT||blaTEM-1B, strAB, tet(34), gyrA, parE, pmrA, pmrB||8|
|11-1896||2010||U||ST58||147; 120; 36; 28; 22; 15; 2||IncFIB, IncFII, IncI1, IncQ1, IncX4||AML, CT, CTX, KF, TE, STX||blaCTX-M-1, blaTEM-1B, strAB, sul2, tet(A), tet(34), dfrA5, gyrB, pmrA, pmrB, phoB, eptB||8|
||A or C
||200; 147; 36
||AMC, AML, CN, CIP, CT, FLO, MAR, NAL, TE, STX
||blaTEM-1A, blaTEM-1B, aadA1, aadA2, aadB, aph(3′)-Ia, aac(3)-Iia, strAB, sul1, sul2, sul3, tet(A), tet(B), tet(34), dfrA1, mcr-1, mef(B), catA1, cmlA1, floR, gyrA, parC, pmrB
|*With the exception of mcr-1 in E. coli 29957, genes shown in bold are located on the chromosome in which nonsynonymous amino acid substitutions were identified in the corresponding proteins (online Technical Appendix Tables 1, 2, http://wwwnc.cdc.gov/EID/article/22/9/16-0140-Techapp1.pdf) known to confer resistance to quinolones and colistin. Plasmid replicon types and mcr-1 genes shown in bold were further confirmed by PCR. AMC, amoxicillin/clavulanate; AML, amoxicillin; CN, gentamicin; CT, colistin; CIP, ciprofloxacin; CTX, cefotaxime; FLO, florfenicol; Inc, incompatibility type, KF, cephalothin; NAL, nalidixic acid; MAR, marbofloxacin; PBRT, PCR-based replicon types; TE, tetracycline; ST, sequence type; STX, trimethoprim/ sulfamethoxazole. †Indicates plasmid replicon types and antimicrobial resistance genotypes extracted from whole genome sequencing data.|
1These authors contributed equally to this article.
2Current affiliation: Trinity College Dublin, Dublin, Ireland.
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