Volume 23, Number 11—November 2017
Dispatch
Long-Term Viruria in Zika Virus–Infected Pregnant Women, Brazil, 2016
Table
Pt. no. |
Week of gestation at virus detection |
Days until first collection |
Sample no., week of gestation/sample type and result/Ct | Week of gestation at birth |
Adverse newborn outcome |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
|||||
1 | 16 | 2 | 16/S+/ 29.34; 16/U+/ 31.31 | 17/U+/33 | 19/U– | 22/U+/38.01 | 24/U– | 27/U– | 31/U– | 36/U+/37.24 | 38 | No | |
2 | 4 | 3 | 4/S+/ 35.62; 4/U+/ 36.39 | 6/U– | 10/U– | 12/U– | 17/U– | 23/U+/38.21 | 28/U+/37.63 | 32/U+/37.58 | 36/U– | 39 | NA |
3 | 30 | 5 | 30/S+/ 37.33; 30/U+/ 25.08 | 32/U– | 34/U+/35.79 | 37/U+/36.42 | 38 | No | |||||
4 | 17 | 4 | 17/S+/33 | 18/U– | 23/U– | 28/U+/38.06 | 32/U+/37.82 | 34/U– | 36/U+/37.03 | 39 | No | ||
5 | 27 | 4 | 29/S+/ 37.35 | 31/U+/36.86 | 33/U– | 35/U– | 36 | Unilateral abnormal OAE | |||||
6 | 14 | 1 | 14/S+/ 33.51; 14/U+/ 32.75 | 14/S–; 15/U+/37.72 | 21/U– | 27/U– | 31/U+/36.59 | 35/U+/36.98 | 38 | No | |||
7 | 14 | 39 | 20/U+/ 38.5 | 22/U– | 27/U+/34.88 | 31/U– | 36/U– | 39 | No | ||||
8 | 15 | 6 | 16/S+/ 37.28; 16/U+/ 34.56 | 18/U– | 23/U+/36.6 | 27/U– | 32/U+/32.68 | 36/U+/36.64 | 39 | No | |||
9 | 17 | 16 | 18/U– | 22/U+/37.58 | 27/U– | 32/U+/37.62 | 38/S– | 38 | No | ||||
10 | 21 | 32 | 26/U– | 28/U– | 32/U– | 35/U+/ 38.1 | 37 | Subependymal cysts | |||||
11 | 5 | 12 | 6/S+/ 37.85 | 14/U– | 19/U– | 23/U– | 27/U+/37.71 | 31/U– | 35/U– | 38 | No | ||
12 | 19 | 47 | 25/U+/ 36.87; 25/S– | 30/U+/36.81 | 32/U+/38.2 | 36/U– | 38 | No | |||||
13 | 24 | 41 | 25/U– | 27/U– | 31/U+/38.15 | 36/U+/33.9 | 37 | Unilateral abnormal OAE |
*Plus signs (+) indicate positive test results (Ct <38.5) and minus signs (–) indicate negative test results (Ct >38.5 or undetermined) (6). All pregnant women initially tested positive for Zika virus RNA. For some women (patient nos. 7, 8, 9, 10, 12, 13), data from the initial samples were not available. Ct, cycle threshold; NA, not available; OAE, otoacoustic emissions; pt., patient; S, serum; U, urine.
References
- Dick GW, Kitchen SF, Haddow AJ. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46:509–20. DOIPubMedGoogle Scholar
- Mota MT, Terzian AC, Silva ML, Estofolete C, Nogueira ML. Mosquito-transmitted viruses - the great Brazilian challenge. Braz J Microbiol. 2016;47(Suppl 1):38–50. DOIPubMedGoogle Scholar
- Brazilian Ministry of Health. Exames laboratoriais [cited 2017 Mar 20]. http://portalsaude.saude.gov.br/index.php/exames-laboratoriais-zika
- Landry ML, St George K. Laboratory diagnosis of Zika virus infection. Arch Pathol Lab Med. 2017;141:60–7. DOIPubMedGoogle Scholar
- Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus. [Erratum in Emerg Infect Dis. 2015;21:552]. Emerg Infect Dis. 2015;21:359–61. DOIPubMedGoogle Scholar
- Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14:1232–9. DOIPubMedGoogle Scholar
- Driggers RW, Ho C-Y, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med. 2016;374:2142–51. DOIPubMedGoogle Scholar
- Mansuy JM, Mengelle C, Pasquier C, Chapuy-Regaud S, Delobel P, Martin-Blondel G, et al. Zika virus infection and prolonged viremia in whole-blood specimens. Emerg Infect Dis. 2017;23:863–5. DOIPubMedGoogle Scholar
- Suy A, Sulleiro E, Rodó C, Vázquez É, Bocanegra C, Molina I, et al. Prolonged Zika virus viremia during pregnancy. N Engl J Med. 2016;375:2611–3. DOIPubMedGoogle Scholar
- Tonry JH, Xiao SY, Siirin M, Chen H, da Rosa APTR, Tesh RB. Persistent shedding of West Nile virus in urine of experimentally infected hamsters. Am J Trop Med Hyg. 2005;72:320–4.PubMedGoogle Scholar
- Oliveira Souto I, Alejo-Cancho I, Gascón Brustenga J, Peiró Mestres A, Muñoz Gutiérrez J, Martínez Yoldi MJ. Persistence of Zika virus in semen 93 days after the onset of symptoms. Enferm Infecc Microbiol Clin. 2016;S0213-005X(16)30341-X.PubMedGoogle Scholar
- Wiwanitkit V. Urine-based molecular diagnosis of Zika virus. Int Urol Nephrol. 2016;48:2023. DOIPubMedGoogle Scholar
- Ma W, Li S, Ma S, Jia L, Zhang F, Zhang Y, et al. Zika virus causes testis damage and leads to male infertility in mice. Cell. 2016;167:1511–1524.e10. DOIPubMedGoogle Scholar
- Gourinat AC, O’Connor O, Calvez E, Goarant C, Dupont-Rouzeyrol M. Detection of Zika virus in urine. Emerg Infect Dis. 2015;21:84–6. DOIPubMedGoogle Scholar
- Bingham AM, Cone M, Mock V, Heberlein-Larson L, Stanek D, Blackmore C, et al. Comparison of test results for Zika virus RNA in urine, serum, and saliva specimens from persons with travel-associated Zika virus disease—Florida, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:475–8. DOIPubMedGoogle Scholar
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