Volume 23, Number 11—November 2017
CME ACTIVITY - Synopsis
Pregnant Women Hospitalized with Chikungunya Virus Infection, Colombia, 2015
Table 2
Criteria for severe acute maternal morbidity among 9 pregnant women with chikungunya virus infection who were admitted to intensive care, Colombia, 2015*
Criteria |
No. (%) patients |
Organ dysfunction† | 7 (77.8) |
Hepatic | 2 (22.2) |
Renal | 3 (33.3) |
Vascular |
2 (22.2) |
Clinical diagnosis | 9 (100) |
Severe preeclampsia | 3 (33.3) |
Severe postpartum hemorrhage | 1 (11.1) |
Sepsis |
9 (100) |
Interventions in critical care | 9 (100) |
Admission to intensive care unit | 9 (100) |
Transfusions of >3 units of red blood cells | 2 (22.2) |
*The World Health Organization’s definition for severe acute maternal morbidity was used (24,25).
†Hepatic dysfunction was defined as hyperbilirubinemia (bilirubin >100 µmol/L or 6 mg/dL). Renal dysfunction was defined as oliguria <400 mL that did not resolve after administration of fluids or diuretics. Vascular dysfunction was defined as hypovolemia requiring transfusion or use of vasoactives.
References
- Dalrymple JPC. Alphaviruses. In: Fields virology. Knipe DM, editor. New York: Raven Press; 1990. p. 713–61.
- Hamer DH, Chen LH. Chikungunya: establishing a new home in the Western hemisphere. Ann Intern Med. 2014;161:827–8. DOIPubMedGoogle Scholar
- Yactayo S, Staples JE, Millot V, Cibrelus L, Ramon-Pardo P. Epidemiology of chikungunya in the Americas. J Infect Dis. 2016;214(suppl 5):S441–5. DOIPubMedGoogle Scholar
- Instituto Nacional de Salud – Dirección de Vigilancia y Análisis del Riesgo en Salud Pública. Boletin epidemiológico semanal. 2016 [cited 2017 Jun 22]. http://www.ins.gov.co/boletin-epidemiologico/Boletn%20Epidemiolgico/2016%20Bolet%C3%ADn%20epidemiol%C3%B3gico%20semana%2051.pdf
- Bodenmann P, Genton B. Chikungunya: an epidemic in real time. Lancet. 2006;368:258. DOIPubMedGoogle Scholar
- Pialoux G, Gaüzère B-A, Jauréguiberry S, Strobel M. Chikungunya, an epidemic arbovirosis. Lancet Infect Dis. 2007;7:319–27. DOIPubMedGoogle Scholar
- Brighton SW, Prozesky OW, de la Harpe AL. Chikungunya virus infection. A retrospective study of 107 cases. S Afr Med J. 1983;63:313–5.PubMedGoogle Scholar
- Fritel X, Rollot O, Gérardin P, Gaūzère BA, Bideault J, Lagarde L, et al.; Chikungunya-Mere-Enfant Team. Chikungunya virus infection during pregnancy, Reunion, France, 2006. Emerg Infect Dis. 2010;16:418–25. DOIPubMedGoogle Scholar
- Robillard P-Y, Boumahni B, Gérardin P, Michault A, Fourmaintraux A, Schuffenecker I, et al. [Vertical maternal fetal transmission of the chikungunya virus. Ten cases among 84 pregnant women]. Presse Med. 2006;35:785–8. DOIPubMedGoogle Scholar
- Gérardin P, Barau G, Michault A, Bintner M, Randrianaivo H, Choker G, et al. Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion. PLoS Med. 2008;5:e60. DOIPubMedGoogle Scholar
- Gérardin P, Couderc T, Bintner M, Tournebize P, Renouil M, Lémant J, et al.; Encephalchik Study Group. Chikungunya virus-associated encephalitis: A cohort study on La Réunion Island, 2005-2009. Neurology. 2016;86:94–102. DOIPubMedGoogle Scholar
- Ramful D, Carbonnier M, Pasquet M, Bouhmani B, Ghazouani J, Noormahomed T, et al. Mother-to-child transmission of Chikungunya virus infection. Pediatr Infect Dis J. 2007;26:811–5. DOIPubMedGoogle Scholar
- Senanayake MP, Senanayake SM, Vidanage KK, Gunasena S, Lamabadusuriya SP. Vertical transmission in chikungunya infection. Ceylon Med J. 2009;54:47–50. DOIPubMedGoogle Scholar
- Villamil-Gómez W, Alba-Silvera L, Menco-Ramos A, Gonzalez-Vergara A, Molinares-Palacios T, Barrios-Corrales M, et al. Congenital chikungunya virus infection in Sincelejo, Colombia: a case series. J Trop Pediatr. 2015;61:386–92. DOIPubMedGoogle Scholar
- Castañeda-Orjuela C, Díaz-Jiménez D, Rodríguez-Castillo L, Paternina-Caicedo A, Pinzón-Redondo H, Alvis-Guzman N, et al. PHS44 - medical care costs of chikungunya virus infection in a pediatric population in Colombia. Value Health. 2015;18:A254–5. DOIGoogle Scholar
- Rodriguez-Morales AJ, Gil-Restrepo AF, Ramírez-Jaramillo V, Montoya-Arias CP, Acevedo-Mendoza WF, Bedoya-Arias JE, et al. Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia. F1000 Res. 2016;5:360. DOIPubMedGoogle Scholar
- Rodríguez-Nieves M, García-García I, García-Fragoso L. Perinatally acquired chikungunya infection: the Puerto Rico experience. Pediatr Infect Dis J. 2016;35:1163. DOIPubMedGoogle Scholar
- Alvarado-Socarras JL, Ocampo-González M, Vargas-Soler JA, Rodriguez-Morales AJ, Franco-Paredes C. Congenital and neonatal chikungunya in Colombia. J Pediatric Infect Dis Soc. 2016;5:e17–20. DOIPubMedGoogle Scholar
- Lyra PPR, Campos GS, Bandeira ID, Sardi SI, Costa LFM, Santos FR, et al. Congenital chikungunya virus infection after an outbreak in Salvador, Bahia, Brazil. AJP Rep. 2016;6:e299–300. DOIPubMedGoogle Scholar
- Torres JR, Falleiros-Arlant LH, Dueñas L, Pleitez-Navarrete J, Salgado DM, Castillo JB-D. Congenital and perinatal complications of chikungunya fever: a Latin American experience. Int J Infect Dis. 2016;51:85–8. DOIPubMedGoogle Scholar
- Laiton-Donato K, Usme-Ciro JA, Rico A, Pardo L, Martínez C, Salas D, et al. Phylogenetic analysis of Chikungunya virus in Colombia: Evidence of purifying selection in the E1 gene. Biomedica. 2015;36:25–34. DOIPubMedGoogle Scholar
- Kucharz EJ, Cebula-Byrska I. Chikungunya fever. Eur J Intern Med. 2012;23:325–9. DOIPubMedGoogle Scholar
- Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al.; SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250–6. DOIPubMedGoogle Scholar
- Mantel GD, Buchmann E, Rees H, Pattinson RC. Severe acute maternal morbidity: a pilot study of a definition for a near-miss. Br J Obstet Gynaecol. 1998;105:985–90. DOIPubMedGoogle Scholar
- Say L, Pattinson RC, Gülmezoglu AM. WHO systematic review of maternal morbidity and mortality: the prevalence of severe acute maternal morbidity (near miss). Reprod Health. 2004;1:3. DOIPubMedGoogle Scholar
- Rodríguez-Morales AJ, Calvache-Benavides CE, Giraldo-Gómez J, Hurtado-Hurtado N, Yepes-Echeverri MC, García-Loaiza CJ, et al. Post-chikungunya chronic arthralgia: Results from a retrospective follow-up study of 131 cases in Tolima, Colombia. Travel Med Infect Dis. 2016;14:58–9. DOIPubMedGoogle Scholar
- Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569–81. DOIPubMedGoogle Scholar
- Thiberville S-D, Boisson V, Gaudart J, Simon F, Flahault A, de Lamballerie X. Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean. PLoS Negl Trop Dis. 2013;7:e2004. DOIPubMedGoogle Scholar
- Economopoulou A, Dominguez M, Helynck B, Sissoko D, Wichmann O, Quenel P, et al. Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion. Epidemiol Infect. 2009;137:534–41. DOIPubMedGoogle Scholar
- Charrel RN, de Lamballerie X. Chikungunya virus in north-eastern Italy: a consequence of seasonal synchronicity. Euro Surveill. 2008;13:8003.PubMedGoogle Scholar
- Borgherini G, Poubeau P, Staikowsky F, Lory M, Le Moullec N, Becquart JP, et al. Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis. 2007;44:1401–7. DOIPubMedGoogle Scholar
- Rollé A, Schepers K, Cassadou S, Curlier E, Madeux B, Hermann-Storck C, et al. Severe sepsis and septic shock associated with chikungunya virus infection, Guadeloupe, 2014. Emerg Infect Dis. 2016;22:891–4. DOIPubMedGoogle Scholar
- Touret Y, Randrianaivo H, Michault A, Schuffenecker I, Kauffmann E, Lenglet Y, et al. [Early maternal-fetal transmission of the Chikungunya virus]. Presse Med. 2006;35:1656–8. DOIPubMedGoogle Scholar
- Lenglet Y, Barau G, Robillard P-Y, Randrianaivo H, Michault A, Bouveret A, et al. [Chikungunya infection in pregnancy: Evidence for intrauterine infection in pregnant women and vertical transmission in the parturient. Survey of the Reunion Island outbreak]. J Gynecol Obstet Biol Reprod (Paris). 2006;35:578–83. DOIPubMedGoogle Scholar
- Panning M, Grywna K, van Esbroeck M, Emmerich P, Drosten C. Chikungunya fever in travelers returning to Europe from the Indian Ocean region, 2006. Emerg Infect Dis. 2008;14:416–22. DOIPubMedGoogle Scholar
- Instituto Nacional de Salud. Protocolo de Vigilancia en Salud Pública. Morbilidad materna extrema. 2016 Mar 29 [cited 2017 Jul 4]. http://www.ins.gov.co/lineas-de-accion/Subdireccion-Vigilancia/sivigila/Protocolos%20SIVIGILA/PRO%20Morbilidad%20Materna%20Extrema.pdf
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