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Volume 23, Number 11—November 2017

Emergence of Bordetella holmesii as a Causative Agent of Whooping Cough, Barcelona, Spain

Alba Mir-Cros, Gema Codina, M. Teresa Martín-Gómez, Anna FàbregaComments to Author , Xavier Martínez, Mireia Jané, Diego Van Esso, Thais Cornejo, Carlos Rodrigo, Magda Campins, Tomàs Pumarola, and Juan José González-LópezComments to Author 
Author affiliations: Hospital Universitari Vall d’Hebron, Barcelona, Spain (A. Mir-Cros, G. Codina, M.T. Martín-Gómez, A. Fàbrega, X. Martínez, T. Cornejo, C. Rodrigo, M. Campins, T. Pumarola, J.J. González-López); Universitat Autònoma de Barcelona, Barcelona (A. Mir-Cros, G. Codina, C. Rodrigo, M. Campins, T. Pumarola, J.J. González-López); Public Health Agency of Catalonia, Barcelona (M. Jané); Primary Care Health Centre Service ‘Muntanya,’ Barcelona (D. Van Esso)

Main Article

Table 2

Comparison of demographic, vaccination-related, clinical characteristics between patients with Bordetella pertussis and B. holmesii infection, Hospital Vall d’Hebron, Barcelona, Spain, 2015–2016*

B. pertussis, n = 40
B. holmesii, n = 10
p value
Median age (range), y 5.5 (0.08–74) 9 (4–40) 0.07
Median pertussis vaccine doses received (range) 4 (0–5) 5 (3–5) 0.21
Median time from last pertussis vaccine dose received to date of diagnosis (range), y 1.92 (0.08–11.70) 3.82 (1.03–14.05) 0.1
Fever, no. (%) 5 (12.5) 1 (10) 1
Whoop, no. (%) 9 (22.5) 1 (10) 0.66
Paroxysms, no. (%) 4 (10) 1 (10) 1
Cough ≥14 d, no. (%) 12 (30) 4 (40) 0.7
Hospitalized, no. (%) 4 (10) 0 0.57

*Differences were assessed for significance using the chi-squared exact test (in comparison with independent qualitative variables) and the Mann-Whitney U-test (for quantitative variables; no normality was observed in data distribution). We selected a randomized sample of confirmed B. pertussis cases with a 4:1 relation with B. holmesii–infected patients as a comparison group. p values <0.05 were considered statistically significant at the 95%
CI level.

Main Article

Page created: October 17, 2017
Page updated: October 17, 2017
Page reviewed: October 17, 2017
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