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Volume 23, Number 2—February 2017
Dispatch

Fatal Infection with Murray Valley Encephalitis Virus Imported from Australia to Canada, 2011

Daniel J. Niven, Kevin Afra, Mircea Iftinca, Raymond Tellier, Kevin Fonseca, Andreas Kramer, David Safronetz, Kimberly Holloway, Michael Drebot, and Andrew S. JohnsonComments to Author 
Author affiliations: University of Calgary, Calgary, Alberta, Canada (D.J. Niven, M. Iftinca, R. Tellier, K. Fonseca, A. Kramer, A.S. Johnson); Fraser Health Authority, Surrey, British Columbia, Canada (K. Afra); Provincial Laboratory for Public Health, Calgary (R. Tellier, K. Fonseca); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (D. Safronetz, K. Holloway, M. Drebot)

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Figure 2

Hematoxylin and eosin–stained autopsy specimens from a patient with a fatal infection of Murray Valley encephalitis virus imported from Australia to Canada, 2011. A) Pons showing perivascular inflammatory infiltrate (original magnification ×40). B) Thalamus showing extensive inflammation (arrows) surrounding an area of rarefaction caused by necrosis (arrowheads) and neuronal loss (original magnification ×10); inset shows a microglial nodule (original magnification ×20). C) Pyramidal cell layer o

Figure 2. Hematoxylin and eosin–stained autopsy specimens from a patient with a fatal infection of Murray Valley encephalitis virus imported from Australia to Canada, 2011. A) Pons showing perivascular inflammatory infiltrate (original magnification ×40). B) Thalamus showing extensive inflammation (arrows) surrounding an area of rarefaction caused by necrosis (arrowheads) and neuronal loss (original magnification ×10); inset shows a microglial nodule (original magnification ×20). C) Pyramidal cell layer of the hippocampus showing extensive acute neuronal death (arrows) (original magnification ×4). D) Cerebellum showing severe depletion of Purkinje neurons and acute neuronal death (arrows and inset [original magnification ×40]) with relative sparing of the internal granule cell layer (arrowheads) and inflammation (short arrows) (original magnification ×10). E) Substantia nigra showing extensive inflammation, acute neuronal death (arrows), neuronophagia (arrowhead), and gliosis (original magnification ×10).

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Page created: January 17, 2017
Page updated: January 17, 2017
Page reviewed: January 17, 2017
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