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Volume 23, Number 5—May 2017

Research Letter

Vertical Transmission of Zika Virus by Aedes aegypti and Ae. albopictus Mosquitoes

Alexander T. CiotaComments to Author , Sean M. Bialosuknia, Dylan J. Ehrbar, and Laura D. Kramer
Author affiliations: Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA (A.T. Ciota, S.M. Bialosuknia, D.J. Ehrbar, L.D. Kramer); State University of New York, School of Public Health, Albany, New York, USA (A.T. Ciota, L.D. Kramer)

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Table

Vertical transmission of Zika virus in Aedes spp. mosquitoes*

Species/ population Zika virus strain Cycle Blood meal titer, log10 PFU/mL % Infected (diss)† Mean body titer, log10 PFU/mL Total no. pools No. individual mosquitoes dpi Zika virus positive FIR‡
(95% CI)
Ae. aegypti
Mexico ZIKV HND All§ 8.9 90.9 (95.0) 7.6 26 130 11–18 1 7.7
(0.5–36.9)
Argentina ZIKV HND All§ 9.3 100 (100) 6.6 28 136 11–38 2 14.9
(2.7–8.3)
Combined¶ ZIKV HND OV2 29 141 11–22 1 7.1
(0.4–4.0)
OV3 23 115 18–38 2 17.7
(3.2–57.2)
OV4 2 10 38 0 <94.6
(6.6–495.8)
Combined¶ ZIKV HND All§ 9.1# 95.5 (97.5) 7.4 54 266 11–38 3 11.5
(3.0–30.8)
Argentina ZIKV PR OV1 24 120 36–38 2 17.0
(3.1–54.8)
OV2 15 75 43–52 0 <13.3
(0.8–63.6)
OV3 4 18 60–62 0 <55.8
(3.4–262.5)
OV4 7 35 63 1 28.5
(1.7–34.8)
ZIKV PR All§ 9.1 100 (100) 7.7 50 248 36–63 3 12.3
(3.3–33)
Combined
Combined**
All§
9.1#
96.9 (98.3)
7.5
104
514
11–63
6
11.9
(4.9–4.6)
Ae. albopictus
New York ZIKV HND All§ 8.9 100 (93.3) 7.1 17 85 11–63 1 11.8
(0.7–56.2)

*Diss, disseminated; dpi, days post infection; FIR, filial infection rate; ZIKV HND, Zika virus Honduras 2016; OV, oviposition; ZIKV PR, Zika virus Puerto Rico.
†Percentage of infected with Zika virus–positive legs.
‡No. Zika virus positive/1,000 larvae.
§Combines data from all hatched eggs.
¶Data for both mosquito populations are combined.
#Mean titer.
**Data for both virus strains are combined.

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