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Volume 23, Number 6—June 2017

Research Letter

Highly Pathogenic Avian Influenza Virus (H5N8) Clade 2.3.4.4 Infection in Migratory Birds, Egypt

Abdullah A. Selim, Ahmed M. Erfan, Naglaa Hagag, Ali Zanaty, Abdel-Hafez Samir, Mohamed Samy, Ahmed Abdelhalim, Abdel-Satar A. Arafa, Mohamed A. Soliman, Momtaz Shaheen, Essam M. Ibraheem, Ibrahim Mahrous, Mohamed K. Hassan, and Mahmoud M. NaguibComments to Author 
Author affiliations: National Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Giza, Egypt (A.A. Selim, A.M. Erfan, N. Hagag, A. Zanaty, A.-H. Samir, M. Samy, A. Abdelhalim, A.-S.A. Arafa, M.A. Soliman, M. Shaheen, E.M. Ibraheem, M.K. Hassan, M.M. Naguib); General Organization for Veterinary Services, Giza (I. Mahrous); Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Insel-Riems, Germany (M.M. Naguib)

Main Article

Figure

Structural and phylogenetic modeling of highly pathogenic avian influenza virus (H5N8), EG-CA285, from migratory birds, Egypt, 2016. A) Three-dimensional structural homology model for the hemagglutinin protein of EG-CA285 created by using the ancestral virus of clade 2.3.4.4b (A/duck/Zhejiang/6D18/2013 [H5N8]) as a template. Amino acids distinguishing the EG-CA285 sequence from the modeling template are shown in red; green depicts unique mutations distinguishing this virus from the virus detecte

Figure. Structural and phylogenetic modeling of highly pathogenic avian influenza virus (H5N8), EG-CA285, from migratory birds, Egypt, 2016. A) Three-dimensional structural homology model for the hemagglutinin protein of EG-CA285 created by using the ancestral virus of clade 2.3.4.4b (A/duck/Zhejiang/6D18/2013 [H5N8]) as a template. Amino acids distinguishing the EG-CA285 sequence from the modeling template are shown in red; green depicts unique mutations distinguishing this virus from the virus detected in summer 2016 in Russia, A/great crested grebe/Uvs-Nuur-Lake/341/2016. B) Phylogenetic tree of the nucleotide sequences of avian influenza virus hemagglutinin genes. Maximum-likelihood calculations were done with IQ-TREE software (http://iqtree.cibiv.univie.ac.at/) under the best-fit model according to the Akaike criterion (general time reversible plus gamma plus G4 model). Red indicates strains from Egypt; green shading indicates strains currently circulating in Europe. Scale bar indicates nucleotide substitutions per site.

Main Article

Page created: May 16, 2017
Page updated: May 16, 2017
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