Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 7—July 2017

Measles Outbreak with Unique Virus Genotyping, Ontario, Canada, 2015

Shari Thomas, Joanne Hiebert, Jonathan B. Gubbay, Effie Gournis, Jennifer Sharron, Alberto Severini, Manisa Jiaravuthisan, Amanda Shane, Valerie Jaeger, Natasha S. Crowcroft, Jill Fediurek, Beate Sander, Tony Mazzulli, Helene Schulz, and Shelley L. DeeksComments to Author 
Author affiliations: Public Health Ontario, Toronto, Ontario, Canada (S. Thomas, J.B. Gubbay, N.S. Crowcroft, J. Fediurek, B. Sander, T. Mazzulli, S.L. Deeks); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (J. Hiebert, A. Severini); University of Toronto, Toronto (E. Gournis, N.S. Crowcroft, B. Sander, T. Mazzulli, S.L. Deeks); Niagara Region Public Health, Niagara Falls, Ontario, Canada (J. Sharron, V. Jaeger); Toronto Public Health, Toronto (M. Jiaravuthisan); Public Health Agency of Canada, Ottawa, Ontario, Canada (A. Shane); University of Manitoba, Winnipeg (A. Severini, H. Schulz)

Main Article

Table 2

Selected characteristics of 18 case-patients identified during a measles outbreak, Ontario, Canada, January 25–March 23, 2015*

Case-patient no.
Date of rash onset
Age, y
Health unit
Immunization status, no. doses
Sequencing of N-450, H gene, and MF-NCR†
1 Jan 25 22 Toronto 0 + Type sequence to which sequences from all other cases are compared
2 Jan 26 39 Toronto 1 + 1 SNP in the H gene (C961T)
3 Jan 27 1 Toronto 0 IND No changes
4 Jan 27 24 York 2 + No changes
5 Jan 29 20 Niagara 0 + No changes
6 Jan 29 55 Toronto Unknown + H gene sequence not determined; otherwise no changes
7 Jan 30 1 Toronto 0 NT 1 SNP in the H gene (C1497T)
8 Jan 31 39 Toronto 2 + 1 SNP in the MF-NCR (G932A)
9 Feb 2 46 Toronto Unknown + No changes
10 Feb 9 35 Halton Unknown + No changes
11 Feb 10 14 Niagara 1 (PEP) No changes
12 Feb 11 34 Toronto 1 + No changes
13 Feb 13 2 Toronto Unknown + No changes
14 Feb 14 10 Niagara 1 (PEP) NT No changes
15 Feb 14 17 Niagara 1 (PEP) NT No changes
16 Feb 14 10 Niagara 1 (PEP) NT No changes
17 Feb 14 23 Niagara 0 NT Not determined (specimens unavailable)
18 Feb 17 41 Toronto 1 + No changes

*H, hemagglutinin; IND, indeterminate; MF-NCR, noncoding region between the matrix and fusion genes; N-450, 450 nt of the nucleoprotein gene; NT, not tested; PEP, postexposure prophylaxis, SNP, single-nucleotide polymorphism.
†All sequence results are in reference to the earliest detected sequence: MVs/Ontario.CAN/3.15 (GenBank accession nos. KU218405, KU218406, and KX396596 for the N-450, H gene, and MF-NCR, respectively), which is designated the “type sequence” for the purposes of this outbreak. The N-450 sequences, which were identical for all 17 cases with sequences, did not match any named lineage in MeaNS, the World Health Organization’s measles sequence database.

Main Article

Page created: June 19, 2017
Page updated: June 19, 2017
Page reviewed: June 19, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.