Volume 23, Number 7—July 2017
Synopsis
Measles Outbreak with Unique Virus Genotyping, Ontario, Canada, 2015
Table 2
Selected characteristics of 18 case-patients identified during a measles outbreak, Ontario, Canada, January 25–March 23, 2015*
Case-patient no. |
Date of rash onset |
Age, y |
Health unit |
Immunization status, no. doses |
IgM |
Sequencing of N-450, H gene, and MF-NCR† |
|
---|---|---|---|---|---|---|---|
1 | Jan 25 | 22 | Toronto | 0 | + | Type sequence to which sequences from all other cases are compared | |
2 | Jan 26 | 39 | Toronto | 1 | + | 1 SNP in the H gene (C961T) | |
3 | Jan 27 | 1 | Toronto | 0 | IND | No changes | |
4 | Jan 27 | 24 | York | 2 | + | No changes | |
5 | Jan 29 | 20 | Niagara | 0 | + | No changes | |
6 | Jan 29 | 55 | Toronto | Unknown | + | H gene sequence not determined; otherwise no changes | |
7 | Jan 30 | 1 | Toronto | 0 | NT | 1 SNP in the H gene (C1497T) | |
8 | Jan 31 | 39 | Toronto | 2 | + | 1 SNP in the MF-NCR (G932A) | |
9 | Feb 2 | 46 | Toronto | Unknown | + | No changes | |
10 | Feb 9 | 35 | Halton | Unknown | + | No changes | |
11 | Feb 10 | 14 | Niagara | 1 (PEP) | – | No changes | |
12 | Feb 11 | 34 | Toronto | 1 | + | No changes | |
13 | Feb 13 | 2 | Toronto | Unknown | + | No changes | |
14 | Feb 14 | 10 | Niagara | 1 (PEP) | NT | No changes | |
15 | Feb 14 | 17 | Niagara | 1 (PEP) | NT | No changes | |
16 | Feb 14 | 10 | Niagara | 1 (PEP) | NT | No changes | |
17 | Feb 14 | 23 | Niagara | 0 | NT | Not determined (specimens unavailable) | |
18 | Feb 17 | 41 | Toronto | 1 | + | No changes |
*H, hemagglutinin; IND, indeterminate; MF-NCR, noncoding region between the matrix and fusion genes; N-450, 450 nt of the nucleoprotein gene; NT, not tested; PEP, postexposure prophylaxis, SNP, single-nucleotide polymorphism.
†All sequence results are in reference to the earliest detected sequence: MVs/Ontario.CAN/3.15 (GenBank accession nos. KU218405, KU218406, and KX396596 for the N-450, H gene, and MF-NCR, respectively), which is designated the “type sequence” for the purposes of this outbreak. The N-450 sequences, which were identical for all 17 cases with sequences, did not match any named lineage in MeaNS, the World Health Organization’s measles sequence database.