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Volume 23, Number 7—July 2017
Dispatch

Locally Acquired mcr-1 in Escherichia coli, Australia, 2011 and 2013

Justin A. Ellem, Andrew N. Ginn, Sharon C.-A. Chen, John Ferguson, Sally R. Partridge, and Jonathan R. IredellComments to Author 
Author affiliations: Westmead Hospital, Westmead, New South Wales, Australia (J.A. Ellem, A.N. Ginn, S.C.-A. Chen, S.R. Partridge, J.R Iredell); New South Wales Health Pathology, Westmead (J.A. Ellem, A.N. Ginn, S.C.-A. Chen, J.R. Iredell); The University of Sydney, Sydney, New South Wales, Australia (A.N. Ginn, S.C.-A. Chen, S.R. Partridge, J.R. Iredell); The Westmead Institute for Medical Research, Westmead (A.N. Ginn, S.R. Partridge, J.R. Iredell); John Hunter Hospital, Newcastle, New South Wales, Australia (J. Ferguson); Pathology North, Newcastle (J. Ferguson); University of Newcastle, Newcastle (J. Ferguson)

Main Article

Table

IncI2 plasmids that carry mcr-1 and are closely related to pJIE2288-1 or pJIE3685-1 from Escherichia coli isolates from separate patients in New South Wales, Australia, 2011 and 2013*

Study plasmid, related plasmids GenBank accession no. Genus and species Source Country Year Insertion sequence
pJIE2288-1 KY795977 E. coli Human urine Australia 2011 –
pEG430-1 LT174530 Shigella sonnei Human feces Vietnam 2008 Apl1
pHSSH22-MCR1 KX856067 Salmonella Typhimurium Human feces China 2012
pHSSH23-MCR1 KX856068 Salmonella Enteritidis Human feces China 2012 Apl1
pHNSHP45 KP347127 E. coli Pig farm China 2013 Apl1, 683
pHeNE867† KU934208 E. coli Chicken China 2013 –
pABC149-MCR-1 KX013538 E. coli Human blood UAE 2013 Apl1
pEc_04HAE12 KX592672 E. coli Human blood China 2014 1
pR150626 KY120366 Salmonella Typhimurium Human Taiwan –
pEC006
 KY471144
 E. coli
South Korea‡
150
pJIE3685-1 KY795978 E. coli Human urine Australia 2011 –
pEC5-1 CP016185 E. coli Chicken liver Malaysia 2013 1
pEC13-1 CP016186 E. coli Pond water Malaysia 2013 –
pS2.14-2 CP016187 E. coli Chicken feed Malaysia 2013 –
pEc_20COE13§ KY012274 E. coli Human blood China 2014 –
pBA77-MCR-1 KX013539 E. coli Human urine Bahrain 2015 1294
pP111 KY120365 Salmonella Typhimurium Pig Taiwan –

*UAE, United Arab Emirates; –,no known insertion sequences were identified. Blank cells indicate that the information is not available.
†Carries mcr-1.3 variant (AA111–2GG) encoding MCR-1.3 with a single (Ile38Val) change from MCR-1 (10).
‡This information is assumed from a GenBank entry rather than from a published report.
§This plasmid has many missing or extra nucleotides in homopolymeric regions compared with all other related plasmids.

Main Article

References
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Page created: June 19, 2017
Page updated: June 19, 2017
Page reviewed: June 19, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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