Volume 23, Number 8—August 2017
Research Letter
Mucus-Activatable Shiga Toxin Genotype stx2d in Escherichia coli O157:H7
Sergio Sánchez1
, María Teresa Llorente, Laura Herrera-León, Raquel Ramiro, Sandra Nebreda, María Antonia Remacha, and Silvia Herrera-León1
, María Teresa Llorente, Laura Herrera-León, Raquel Ramiro, Sandra Nebreda, María Antonia Remacha, and Silvia Herrera-León1
Table
Virulence gene profile of the stx2d-positive Shiga toxin–producing Escherichia coli O157:H7 strain CNM-2140/12*
| Virulence factor | Identity | Protein function | GenBank accession no. |
|---|---|---|---|
| ehxA | 100.00 | Enterohemolysin | AB011549 |
| etpD | 100.00 | Type II secretion protein | AB011549 |
| nleA | 100.00 | Non-LEE encoded effector A | AE005174 |
| espP | 99.92 | Extracellular serine protease plasmid-encoded | AB011549 |
| nleB | 99.90 | Non-LEE encoded effector B | AE005174 |
| gad | 98.50 | Glutamate decarboxylase | BA000007 |
| iss | 98.30 | Increased serum survival | CP001509 |
| eae | 100.00 | Intimin | AF071034 |
| iha | 100.00 | Adherence protein | AE005174 |
| tir | 100.00 | Translocated intimin receptor protein | EU871626 |
| stx2B | 100.00 | Shiga toxin 2, subunit B, variant c | AB071845 |
| iss | 98.54 | Increased serum survival | CU928160 |
| astA | 100.00 | EAST-1 heat-stable toxin | HM099897 |
| astA | 91.96 | EAST-1 heat-stable toxin | AB042005 |
| nleC | 100.00 | Non-LEE encoded effector C | AP010960 |
| espA | 100.00 | Type III secretions system | AE005174 |
| gad | 98.50 | Glutamate decarboxylase | BA000007 |
| nleB | 99.90 | Non-LEE encoded effector B | AE005174 |
| espJ | 99.85 | Prophage-encoded type III secretion system effector | AE005174 |
| katP | 100.00 | Plasmid-encoded catalase peroxidase | AB011549 |
| espB | 100.00 | Secreted protein B | AE005174 |
| nleC | 100.00 | Non-LEE encoded effector C | AE005174 |
| stx2B | 100.00 | Shiga toxin 2, subunit B, variant d | EF584538 |
*Determined from raw whole-genome sequence data using VirulenceFinder (https://cge.cbs.dtu.dk//services/all.php). A percent identity threshold of 90% between the input and the best matching database gene was selected. Bold indicates the mucus-activatable Shiga toxin genotype. EAST, enteroaggregative E. coli heat-stable enterotoxin; LEE, locus of enterocyte effacement.
1These authors contributed equally to this article.
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