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Volume 24, Number 10—October 2018
Dispatch

Multilocus Sequence Typing of Mycoplasma pneumoniae, Japan, 2002–2016

Mariko Ando1, Miyuki Morozumi1, Yoko Adachi, Kimiko Ubukata, and Satoshi IwataComments to Author 
Author affiliations: Keio University School of Medicine, Tokyo, Japan (M. Ando, M. Morozumi, Y. Adachi, K. Ubukata, S. Iwata); National Cancer Center Hospital, Tokyo (S. Iwata)

Main Article

Table 1

Antimicrobial activity of 6 antimicrobial agents against 417 Mycoplasma pneumoniae strains, Japan, 2002–2016*

Antimicrobial agent and M. pneumoniae macrolide-resistance level
 MIC, μg/mL†
50%
 90%
 Range
Clarithromycin
Susceptible 0.0039 0.0078 0.00195 to 0.031
Resistant
 64
 >64
 0.5 to >64
Azithromycin
Susceptible 0.00049 0.00098 0.00012 to 0.00195
Resistant
 64
 64
 0.031 to >64
Minocycline
Susceptible 0.5 1 0.031 to 1
Resistant
 0.25
 1
 0.063 to 1
Doxycycline
Susceptible 0.5 0.5 0.063 to 0.5
Resistant
 0.25
 0.5
 0.125 to 0.5
Levofloxacin
Susceptible 0.5 1 0.125 to 1
Resistant
 0.5
 1
 0.5 to 1
Tosufloxacin
Susceptible 0.5 0.5 0.25 to 1
Resistant 0.5 0.5 0.25 to 2

*Macrolide-susceptible M. pneumoniae = 232; macrolide-resistant M. pneumoniae = 185.
†MIC ranges for macrolides were 16 to >64 μg/mL for A2063G (n = 163) and A2064G (n = 10) and >64 μg/mL for A2063C (n = 1).
MIC for azithromycin was affected by the mutations A2063T (1–4 μg/mL) (n = 10) and C2617A (0.031 μg/mL) (n = 1). MIC for clarithromycin was affected by C2617A (0.5 μg/mL). MICs for quinolone and tetracycline in both macrolide-susceptible and macrolide-resistant M. pneumoniae were almost the same.

Main Article

1These authors contributed equally to this article.

Page created: September 14, 2018
Page updated: September 14, 2018
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