Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 12—December 2018
Research

Emerging Multidrug-Resistant Hybrid Pathotype Shiga Toxin–Producing Escherichia coli O80 and Related Strains of Clonal Complex 165, Europe

Aurélie Cointe, André Birgy, Patricia Mariani-Kurkdjian, Sandrine Liguori, Céline Courroux, Jorge Blanco, Sabine Delannoy, Patrick Fach, Estelle Loukiadis, Philippe Bidet, and Stéphane BonacorsiComments to Author 
Author affiliations: Hôpital Robert-Debré (AP-HP),; Paris, France (A. Cointe, A. Birgy, P. Mariani-Kurkdjian, S. Liguori, C. Courroux, P. Bidet, S. Bonacorsi); Université Paris Diderot, Sorbonne Paris Cité, Paris (A. Cointe, A. Birgy, P. Mariani-Kurkdjian, P. Bidet, S. Bonacorsi); Universidade de Santiago de Compostela, Lugo, Spain (J. Blanco); ANSES, Plateforme IdentyPath, Maisons-Alfort, France (S. Delannoy, P. Fach); Université de Lyon, CNRS, INRA, UCBL, VetAgro Sup, Laboratoire d’Écologie Microbienne, Villeurbanne, France (E. Loukiadis)

Main Article

Figure 1

Genetic characterization of RDEx444, a strain of Escherichia coli serotype O80:H2 isolated in France in February 2016 and involved in hemolytic uremic syndrome with bacteremia, carrying both intestinal and extraintestinal virulence factors associated with (multidrug-resistance determinants (A) and genetic comparison between plasmid pS88 and mosaic plasmid pR444_A (B). A) Four circularized contigs (chromosome of 5,256,050 bp and the 3 plasmids pR444_A [176,500 bp], pR444_B [117,090 bp], and pR444

Figure 1. Genetic characterization of RDEx444, a strain of Escherichia coli serotype O80:H2 isolated in France in February 2016 and involved in hemolytic uremic syndrome with bacteremia, carrying both intestinal and extraintestinal virulence factors associated with (multidrug-resistance determinants (A) and genetic comparison between plasmid pS88 and mosaic plasmid pR444_A (B). A) Four circularized contigs (chromosome of 5,256,050 bp and the 3 plasmids pR444_A [176,500 bp], pR444_B [117,090 bp], and pR444_C [95,050 bp]) obtained by using PacBio (Pacific Biosciences, Meno Park, CA, USA) sequencing of RDEx444 are schematically represented. The main virulence factors are presented as colored rectangles. Intestinal virulence factors are indicated in red for the locus of enterocyte effacement genes, blue for prophage-encoded Shiga toxin genes, and green for VFs carried by pR444_C, a pO157-like plasmid. Bacteriocin genes (mch, cia, and cma) are indicated in yellow. B) Comparison of the sequences of pR444_A and pS88, the plasmid of strain S88 involved in neonatal meningitis. LEE, locus of enterocyte effacement.

Main Article

Page created: November 20, 2018
Page updated: November 20, 2018
Page reviewed: November 20, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external