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Volume 24, Number 12—December 2018
Research

Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway

Laura Pirisinu, Linh Tran, Barbara Chiappini, Ilaria Vanni, Michele A. Di Bari, Gabriele Vaccari, Turid Vikøren, Knut Ivar Madslien, Jørn Våge, Terry Spraker, Gordon Mitchell, Aru Balachandran, Thierry Baron, Cristina Casalone, Christer M. Rolandsen, Knut H. Røed, Umberto Agrimi, Romolo Nonno, and Sylvie L. BenestadComments to Author 
Author affiliations: Istituto Superiore di Sanità, Rome, Italy (L. Pirisinu, B. Chiappini, I. Vanni, M.A. Di Bari, G. Vaccari, U. Agrimi, R. Nonno); Norwegian Veterinary Institute, Oslo, Norway (L. Tran, T. Vikøren, K.I. Madslien, J. Våge, S.L. Benestad); Colorado State University, Fort Collins, Colorado, USA (T. Spraker); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (G. Mitchell, A. Balachandran); Anses Lyon Unité “Maladies Neuro-Dégénératives,” Lyon, France (T. Baron); Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d’Aosta, Torino, Italy (C. Casalone); Norwegian Institute for Nature Research, Trondheim, Norway (C.M. Rolandsen); Norwegian University of Life Sciences, Faculty of Veterinary Science, Oslo (K.H. Røed)

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Table

Summary characteristics of samples used in a study characterizing chronic wasting disease in moose (Alces alces), Norway*

Animal or species Geographic origin Age Pathologic phenotype PrP genotype†
Moose no. 1 Norway 13 y Atypical CWD KK109MM209
Moose no. 2 Norway 14 y Atypical CWD KK109MM209
Moose no. 3 Norway 13 y Atypical CWD KK109MM209
Reindeer Norway 3–4 y CWD VV2GG129SS138VV169
Elk or wapiti Canada 6 y CWD MM132
Elk or wapiti Canada Adult CWD MM132
Elk or wapiti Canada 6 y CWD MM132
White-tailed deer Canada 4 y CWD GG96
Moose Canada Adult CWD KK109II209
Sheep Italy 2.5 y Classical scrapie AA136RR154QQ171
Sheep Italy Adult Classical scrapie AA136RR154QQ171
Sheep Italy 4.5 y Atypical/Nor98 scrapie AA136RH154QQ171
Sheep Experimental sample NA Scrapie CH1641§ AA136HH154QQ171
Sheep France NA Scrapie CH1641-like¶ AA136RR154QQ171
Cattle Italy 6 y C-BSE NA
Cattle Italy 15 y L-BSE NA
Cattle France 11 y H-BSE NA

*All samples were from naturally infected animals, with the exception of 1 sheep experimentally inoculated with CH1641. BSE, bovine spongiform encephalopathy; C-BSE, classical BSE; CWD, chronic wasting disease; H-BSE, H-type atypical BSE; L-BSE, L-type atypical BSE; NA, not available; PrP, prion protein.
†The PrP genotype reported is expressing the amino acid variants present at the major polymorphic codons described for each species.
‡The Canada isolate was homozygous for lysine at codon 109 and for isoleucine at codon 209 (KK109II209) (GenBank accession no. MH230114).
§Reference (9).
¶Reference (10).

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Page created: November 20, 2018
Page updated: November 20, 2018
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