Volume 24, Number 4—April 2018
Research
Carbapenem-Nonsusceptible Acinetobacter baumannii, 8 US Metropolitan Areas, 2012–2015
Table 4
Antimicrobial susceptibility of 621 carbapenem-nonsusceptible Acinetobacter baumannii isolates reported by local clinical laboratories in Emerging Infections Program sites, United States, 2012–2015*
Antimicrobial agent | No. susceptible isolates/no. isolates tested (%) |
p value† | ||
---|---|---|---|---|
Total (%) | Sterile site cultures, n = 173 | Urine cultures, n = 425 | ||
Any aminoglycoside‡ | 421/577 (72.9) | 123/166 (74.1) | 298/411 (72.5) | 0.70 |
Tobramycin | 308/541 (56.9) | 92/158 (58.2) | 216/383 (56.4) | 0.70 |
Amikacin | 254/416 (61.1) | 71/121 (58.7) | 183/295 (62.0) | 0.52 |
Gentamicin |
175/571 (30.7) |
49/163 (30.1) |
126/408 (30.9) |
0.85 |
Any fluoroquinolone‡ | 20/575 (3.5) | 1/164 (0.6) | 19/411 (4.6) | 0.02 |
Levofloxacin | 15/432 (3.5) | 1/120 (0.8) | 14/312 (4.5) | 0.08 |
Ciprofloxacin |
10/522 (1.9) |
1/145 (0.7) |
9/377 (2.4) |
0.30 |
Any extended-spectrum β-lactam‡ | 114/577 (19.8) | 27/165 (16.4) | 87/412 (21.1) | 0.20 |
Ceftazidime | 72/447 (16.1) | 17/129 (13.2) | 55/318 (17.3) | 0.28 |
Cefepime | 68/562 (12.1) | 18/161 (11.2) | 50/401 (12.5) | 0.67 |
Piperacillin/tazobactam |
4/113 (3.5) |
1/37 (2.7) |
3/76 (1.9) |
>0.99 |
Other | ||||
Ampicillin/sulbactam | 180/498 (36.1) | 47/146 (32.2) | 133/352 (37.8) | 0.24 |
Colistin | 114/122 (93.4) | 36/39 (92.3) | 78/83 (94.0) | 0.73 |
Trimethoprim/sulfamethoxazole | 83/483 (17.2) | 26/142 (18.3) | 57/341 (16.7) | 0.67 |
Tigecycline | 74/120 (61.7) | 27/40 (67.5) | 47/80 (58.8) | 0.35 |
*The study areas were Denver, Colorado; Atlanta, Georgia; Baltimore, Maryland; Minneapolis/Saint Paul, Minnesota, Albuquerque, New Mexico; Rochester, New York; Portland, Oregon; Nashville, Tennessee.
†The χ2 test or Fisher exact test was used to test the null hypothesis “carbapenem-nonsusceptible A. baumannii isolates antimicrobial susceptibility did not differ for sterile site vs. urine cultures.” Fisher exact test was used when >1 cell sizes was <5.
‡Includes the antimicrobial drugs listed below.