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Volume 24, Number 6—June 2018

Detection of Low Pathogenicity Influenza A(H7N3) Virus during Duck Mortality Event, Cambodia, 2017

Annika Suttie, Sokhoun Yann, Phalla Y, Sothyra Tum, Yi-Mo Deng, Vibol Hul, Viseth Srey Horm, Ian Barr, Andrew Greenhill, Paul F. Horwood, Kristina Osbjer, Erik A. Karlsson, and Philippe DussartComments to Author 
Author affiliations: Institut Pasteur du Cambodge, Phnom Penh, Cambodia (A. Suttie, S. Yann, P. Y, V. Hul, V.S. Horm, E.A. Karlsson, P. Dussart); Federation University, Churchill, Victoria, Australia (A. Suttie, A. Greenhill); National Animal Health and Production Research Institute, Cambodia Ministry of Agriculture, Forestry and Fisheries, Phnom Penh (S. Tum); World Health Organization Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia (Y.-M. Deng, I. Barr); James Cook University, Cairns, Queensland, Australia (P.F. Horwood); Food and Agriculture Organization of the United Nations, Phnom Penh (K. Osbjer)

Main Article

Table 2

Genetic risk characteristics of influenza A virus subtype H7N3 isolates, Cambodia*

Gene segment and risk factor
Amino acid change
Isolates in Cambodia
Mammalian host range marker and increased viral pathogenicity
E627K E Avian specificity
Multibasic cleavage site causing increased pathogenicity Multibasic PEPPKGR/GLF Monobasic (10)
Increased mammalian receptor specificity
Q226L‡ Q Avian specificity
Resistance to NA inhibitor antivirals
H275Y§ H Sensitive to oseltamivir
E119K¶ E
Resistance to M2 inhibitor antivirals L26F Q Sensitive to M2 inhibitors (13)
V27A R
A30T D
S31N V
G34E G

*HA, hemagglutinin; MP, matrix protein; MP2, matrix protein 2; NA, neuraminidase; PB2, polymerase basic protein 2.
†Receptor binding specificity and antiviral sensitivity is predicted based on sequence information and has not been experimentally confirmed.
‡H3 numbering.
§N1 numbering.
¶N2 numbering.

Main Article

Page created: May 29, 2018
Page updated: May 29, 2018
Page reviewed: May 29, 2018
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