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Volume 24, Number 6—June 2018
Dispatch

Detection of Low Pathogenicity Influenza A(H7N3) Virus during Duck Mortality Event, Cambodia, 2017

Annika Suttie, Sokhoun Yann, Phalla Y, Sothyra Tum, Yi-Mo Deng, Vibol Hul, Viseth Srey Horm, Ian Barr, Andrew Greenhill, Paul F. Horwood, Kristina Osbjer, Erik A. Karlsson, and Philippe DussartComments to Author 
Author affiliations: Institut Pasteur du Cambodge, Phnom Penh, Cambodia (A. Suttie, S. Yann, P. Y, V. Hul, V.S. Horm, E.A. Karlsson, P. Dussart); Federation University, Churchill, Victoria, Australia (A. Suttie, A. Greenhill); National Animal Health and Production Research Institute, Cambodia Ministry of Agriculture, Forestry and Fisheries, Phnom Penh (S. Tum); World Health Organization Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia (Y.-M. Deng, I. Barr); James Cook University, Cairns, Queensland, Australia (P.F. Horwood); Food and Agriculture Organization of the United Nations, Phnom Penh (K. Osbjer)

Main Article

Table 2

Genetic risk characteristics of influenza A virus subtype H7N3 isolates, Cambodia*

Gene segment and risk factor
 Amino acid change
 Isolates in Cambodia
 Conclusions†
 Reference
PB2
Mammalian host range marker and increased viral pathogenicity
 E627K E Avian specificity
 (9)
D701N
 D
HA
Multibasic cleavage site causing increased pathogenicity Multibasic PEPPKGR/GLF Monobasic (10)
Increased mammalian receptor specificity
 Q226L‡ Q Avian specificity
 (11)
G228S‡
 G
NA
Resistance to NA inhibitor antivirals
 H275Y§ H Sensitive to oseltamivir
 (12)
E119K¶ E
R292K
 R
MP
Resistance to M2 inhibitor antivirals L26F Q Sensitive to M2 inhibitors (13)
V27A R
A30T D
S31N V
G34E G

*HA, hemagglutinin; MP, matrix protein; MP2, matrix protein 2; NA, neuraminidase; PB2, polymerase basic protein 2.
†Receptor binding specificity and antiviral sensitivity is predicted based on sequence information and has not been experimentally confirmed.
‡H3 numbering.
§N1 numbering.
¶N2 numbering.

Main Article

Page created: May 29, 2018
Page updated: May 29, 2018
Page reviewed: May 29, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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