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Volume 24, Number 7—July 2018
Research

Geographically Diverse Clusters of Nontoxigenic Corynebacterium diphtheriae Infection, Germany, 2016–2017

Alexandra Dangel1Comments to Author , Anja Berger1, Regina Konrad, Heribert Bischoff, and Andreas Sing
Author affiliations: Bavarian Health and Food Safety Authority, Oberschleissheim, Germany (A. Dangel, A. Berger, R. Konrad, H. Bischoff, A. Sing); German Consiliary Laboratory on Diphtheria, Oberschleissheim (A. Berger, R. Konrad, A. Sing)

Main Article

Figure 2

Enhancement of phylogenetic analysis depth of the 41 nontoxigenic sequence type 8 Corynebacterium diphtheriae isolates submitted from northern Germany, January 2015–June 2017, and reference genome. A) Phylogenetic minimum-spanning tree of isolates analyzed by extended core-genome multilocus sequence typing (cg-MLST), based on 2,154 target loci. Allele distances between isolates are indicated. Grey indicates subclusters with allele difference <5; white indicates the reference genome (BX248353)

Figure 2. Enhancement of phylogenetic analysis depth of the 41 nontoxigenic sequence type 8 Corynebacterium diphtheriae isolates submitted from northern Germany, January 2015–June 2017, and reference genome. A) Phylogenetic minimum-spanning tree of isolates analyzed by extended core-genome multilocus sequence typing (cg-MLST), based on 2,154 target loci. Allele distances between isolates are indicated. Gray indicates subclusters with allele difference <5; white indicates the reference genome (BX248353). B) Phylogenetic maximum-likelihood tree based on genome-wide single-nucleotide polymorphism profiles. From left to right, the color-coded columns indicate isolate affiliations to submitting city, isolate submission year, cg-MLST cluster based on allelic difference of <5 alleles out of 1,553 cg-MLST target loci, and extended cg-MLST-subclusters based on allelic difference of <5 alleles out of 1,553 plus 601 extended cg-MLST target loci. Relative distances are based on 30 000 genomic positions. Scale bar indicates the portion of relative distances based on 14,920 distinct aligned positions.

Main Article

1These authors contributed equally to this article.

Page created: June 18, 2018
Page updated: June 18, 2018
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