Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 7—July 2018

Adenovirus Type 4 Respiratory Infections among Civilian Adults, Northeastern United States, 2011–2015

On This Page
Article Metrics
citations of this article
EID Journal Metrics on Scopus

Cite This Article

To the Editor: We read with interest the article by Kajon et al. (1), which highlighted that human adenovirus type 4 might be an underrecognized cause of acute respiratory disease (ARD) outside military settings. We report that human adenovirus B7 (HAdV-B7) might also be a cause of this disease.

HAdV-B7 is well recognized as a causative agent of neonatal disease and infections in immunocompromised patients. However, we identified an unusual cluster of 4 cases of severe ARD caused by this pathogen in immunocompetent adults in Dublin, Ireland. These patients had acute respiratory illness when they came to the emergency department of Mater Misericordiae University Hospital in Dublin. The patients came to the hospital over a 4-week period during the summer of 2017, and each patient required intensive care support for single-organ failure. Three patients required intubation and ventilation; all 4 patients recovered.

Three patients reported gastrointestinal and respiratory symptoms, as seen in Oregon, USA (2). Although co-infection with other viruses or bacteria has been described (3), only 1 patient in our cluster had a possible concomitant pathogen. None of the 4 patients were given antiviral therapy but all received antimicrobial drugs.

All 4 case-patients were either homeless or in temporary accommodations for homeless adults, but we did not identify any epidemiologic link. The Department of Public Health and temporary accommodation sites were notified to raise awareness and offer early testing of symptomatic persons. However, no additional cases were identified.

HAdV-B7 was identified by BLAST analysis ( of viral hexon genes (4). Each virus had 100% identity within the region sequenced to a strain previously associated with respiratory illness in a military training camp in China (GenBank accession no. KP896481).

This cluster of HAdV-B7 causing severe ARD in immunocompetent adults appears to have no clear epidemiologic link. We agree that HAdV might be an underrecognized pathogen in severe community-onset ARD. Testing for viral respiratory pathogens should be considered in all patients and not just the immunocompromised.


Breda L. LynchComments to Author , Jonathan Dean, Deirdre Brady, and Cillian De Gascun
Author affiliations: Mater Misericordiae University Hospital, Dublin, Ireland (B.L. Lynch, D. Brady); National Virus Reference Laboratory, Dublin (J. Dean, C. De Gascun)



  1. Kajon  AE, Lamson  DM, Bair  CR, Lu  X, Landry  ML, Menegus  M, et al. Adenovirus type 4 respiratory infections among civilian adults, northeastern United States, 2011–2015. Emerg Infect Dis. 2018;24:2019. DOIPubMedGoogle Scholar
  2. Scott  MK, Chommanard  C, Lu  X, Appelgate  D, Grenz  L, Schneider  E, et al. Human adenovirus associated with severe respiratory infection, Oregon, USA, 2013–2014. Emerg Infect Dis. 2016;22:104451. DOIPubMedGoogle Scholar
  3. Berciaud  S, Rayne  F, Kassab  S, Jubert  C, Faure-Della Corte  M, Salin  F, et al.; Typadeno Study Members. Adenovirus infections in Bordeaux University Hospital 2008-2010: clinical and virological features. J Clin Virol. 2012;54:3027. DOIPubMedGoogle Scholar
  4. Casas  I, Avellon  A, Mosquera  M, Jabado  O, Echevarria  JE, Campos  RH, et al. Molecular identification of adenoviruses in clinical samples by analyzing a partial hexon genomic region. J Clin Microbiol. 2005;43:617682. DOIPubMedGoogle Scholar


Cite This Article

DOI: 10.3201/eid2407.180137

Related Links


Table of Contents – Volume 24, Number 7—July 2018

EID Search Options
presentation_01 Advanced Article Search – Search articles by author and/or keyword.
presentation_01 Articles by Country Search – Search articles by the topic country.
presentation_01 Article Type Search – Search articles by article type and issue.



Please use the form below to submit correspondence to the authors or contact them at the following address:

Breda L. Lynch, Department of Clinical Microbiology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland

Send To

10000 character(s) remaining.


Page created: June 18, 2018
Page updated: June 18, 2018
Page reviewed: June 18, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.