Hypoglycemic Toxins and Enteroviruses as Causes of Outbreaks of Acute Encephalitis-Like Syndrome in Children, Bac Giang Province, Northern Vietnam
Nga Thi Phan
1, Meriadeg Ar Gouilh
1, Juliette Paireau, Loan Phuong, Justine Cheval, Nghia Duy Ngu, Charles Hébert, Tuan Hai Nguyen, Olivier Lortholary, Laura Tondeur, Jean-Claude Manuguerra, Robert Barouki, Johannes Sander, Nils Janzen, Hien Tran Nguyen, Paul T. Brey, Arnaud Fontanet
2, and Marc Eloit
2
Author affiliations: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam (N.T. Phan, L.P. Do, N.D. Ngu, T.H. Nguyen, H.T. Nguyen); Institut Pasteur, Paris, France (M. Ar Gouilh, J. Paireau, L. Tondeur, J.-C. Manuguerra, A. Fontanet, M. Eloit); Centre National de la Recherche Scientifique, Paris (J. Paireau); Pathoquest, Paris (J. Cheval, C. Hébert, M. Eloit); Hôpital Necker-Enfants Malades, Paris (O. Lortholary, R. Barouki); Université Paris Descartes, Paris (O. Lortholary, R. Barouki); Institut National de la Santé et de la Recherche Médicale, Paris (R. Barouki); Screening Laboratory Hannover, Hannover, Germany (J. Sander, N. Janzen); Hannover Medical School, Hannover (N. Janzen); Institut Pasteur du Laos, Vientiane, Laos (P.T. Brey); Conservatoire National des Arts et Métiers, Paris (A. Fontanet)
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Figure 3
Figure 3. Serum concentrations of toxins and fatty acids in children with encephalitis-like syndrome, Bac Giang Province, northern Vietnam, 2008–2011. Children were grouped by high (group 1, n = 9, [circles]) and low (group 2, n = 11, [triangles]) serum concentrations of toxins. A) Hypoglycin A; B) MCPF-carnitine (methylenecyclopropylglycine metabolite); C) MCPF-glycine (methylenecyclopropylglycine metabolite); D) octanoylcarnitine (medium-chain fatty acid); E) tetradecenoylcarnitine (long-chain fatty acid in the form of acylcarnitine); and F) palmitoylcarnitine (long-chain fatty acid in the form of acylcarnitine). Horizontal lines indicate medians. MCPF, methylenecyclopropylformyl.
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