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Volume 25, Number 10—October 2019
Synopsis

Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015

Maria D. Van Kerkhove1Comments to Author , Sadoof Alaswad, Abdullah Assiri, Ranawaka A.P.M. Perera, Malik Peiris, Hassan E. El Bushra, and Abdulaziz A. BinSaeed2
Author affiliations: Institut Pasteur, Paris, France (M.D. Van Kerkhove); Ministry of Health, Riyadh, Saudi Arabia (S. Alaswad, A. Assiri, H.E. El Bushra, A.A. BinSaeed); Jubail General Hospital, Riyadh (S. Alaswad); The University of Hong Kong, Hong Kong, China (R.A.P.M. Perera, M. Peiris); HKU-Pasteur Research Pole, Hong Kong (M. Peiris)

Main Article

Table 2

Characteristics of the MERS-CoV–positive participants identified from molecular and serologic assay results, Riyadh, Saudi Arabia, 2015*

Age, y Bldg no. Signs/ symptoms† Symptom onset date RT-PCR‡ Serologic test
SI ELISA
 ppNT
 PRNT90
 Serologic test result§
First sample Second sample First sample Second sample First sample Second sample
23 1B Yes Oct 11 + 1.586 0.523 80 20 20 10 +
28 5B Yes Oct 14 + 2.225 NA 80 NA 40 NA +
29 2A Yes Oct 13 + 1.181 NA 20 NA 10 NA +
29 2A Yes Oct 14 + 4.57 NA 160 NA 80 NA +
28 2A Yes Oct 1 + 3.154 2.741 160 160 40 40 +
26 2A Yes Oct 7 + 3.154 NA 160 NA 40 NA +
39 2A Yes Sep 30 + 1.553 NA 40 NA 20 NA +
53 2A No NS + 4.242 NA 160 NA 80 NA +
41 1B No NS NA 1.311 0.33 20 10 10 <10 +
37 2A Yes Oct 10 – 1.214 0.569 40 20 10 <10 +
30 2A Yes Oct 22 – 0.759 0.605 20 20 0 <10 +
24 2A Yes Oct 1 – 1.422 NA 80 NA 20 NA +
32 2A Yes Sep 26 – 3.381 1.012 80 20 20 10 +
28 2A Yes Sep 19 – 1.999 1.654 40 40 10 20 +
30 1A No NS NA 3.295 1.496 40 20 10 <10 +
36 2B No NS – 1.419 NA 20 NA 20 NA +
42 7A No NS NA 0.576 NA 10 NA 20 NA +
37 10A No NS NA 1.115 NA 80 NA 80 NA +
45 2A No NS – 1.111 0.563 20 20 <10 <10 +

*First samples collected November 13, 2015; second samples collected March 22, 2015. Bldg, building; CoV, coronavirus; MERS, Middle East respiratory syndrome; NA, not available/not collected; NS, no signs/symptoms reported; ppNT, pseudoparticle neutralization test; PRNT90, 90% plaque-reduction neutralization test; RT-PCR, reverse transcription PCR; +, positive; –, negative.
†Self-reported or observed signs/symptoms in the 14 d before epidemiologic interview.
‡According to World Health Organization criteria (http://www.who.int/csr/disease/coronavirus_infections/mers-laboratory-testing).
§Serologic test result was defined as positive if either PRNT90 or ppNT titers were >20. S1 ELISA results are shown for information only; they were not used in designating infection status.

Main Article

1Current affiliation: World Health Organization, Geneva, Switzerland.

2Current affiliation: King Saud University, Riyadh, Saudi Arabia.

Page created: September 25, 2019
Page updated: September 25, 2019
Page reviewed: September 25, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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