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Volume 25, Number 2—February 2019
Online Report

Public Health–Driven Research and Innovation for Next-Generation Influenza Vaccines, European Union

Adoración Navarro-TornéComments to Author , Finnian Hanrahan, Barbara Kerstiëns, Pilar Aguar, and Line Matthiessen
Author affiliations: European Commission Directorate-General for Research and Innovation, Brussels, Belgium

Main Article

Table 2

Challenges in the roadmap for the next-generation influenza vaccines

Challenge types
Eliciting adequate cross-protective humoral and cell-mediated immune response
Selection and delivery of immunogens
Alternatives to egg-based vaccine production
Immunosenescence, “inflammaging” (adjuvants, high-dose vaccine, alternative routes of delivery)
Optimal animal models
Vaccine profiling for different target groups, priming, booster, etc.
New approaches for elucidation of mechanistic aspects of vaccine safety and efficacy (i.e., systems vaccinology)
Design of optimal placebo-controlled clinical trials (when ethical) and with active comparator
Identification of immune correlates of protection
Harmonization and standardization of immunoassays to measure correlates of protection
Human challenge studies
Prospective longitudinal cohort studies for evaluation of influenza immunity and effectiveness of influenza immunization
Planning for postmarketing surveillance
Development cost
Public health
Selection of meaningful endpoints: preventing severe or overt disease vs. blocking infection or transmission
Defining target groups and vaccination schemes
Logistics of vaccine implementation and delivery
Vaccine access
Vaccine supplies and stockpiling
Influenza vaccination for resource-poor settings
Influenza disease and vaccine misperceptions;
Vaccine hesitancy
Funding mechanisms for vaccine development
Cost-effectiveness of universal influenza vaccines

Main Article

Page created: January 18, 2019
Page updated: January 18, 2019
Page reviewed: January 18, 2019
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