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Volume 25, Number 3—March 2019
Dispatch

Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia

Irena Arandjelović1Comments to Author , Matthias Merker1, Elvira Richter, Thomas A. Kohl, Branislava Savić, Ivan Soldatović, Thierry Wirth, Dragana Vuković1, and Stefan Niemann1
Author affiliations: University of Belgrade, Belgrade, Serbia (I. Arandjelović, B. Savić, I. Soldatović, D. Vuković); Leibniz-Zentrum für Medizin und Biowissenschaften, Borstel, Germany (M. Merker, T.A. Kohl, S. Niemann); Laboratory Limbach, Heidelberg, Germany (E. Richter); Paris Sciences & Lettres University, Paris, France (T. Wirth); Sorbonne Universités, Paris (T. Wirth); German Center for Infection Research, Borstel, Germany (S. Niemann)

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Figure 1

Maximum-likelihood phylogeny, applying a general time-reversible substitution model, of 103 multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) isolates from Serbia sampled during 2008–2014. Orange squares indicate MDR MTBC isolates associated with putative transmission chains (molecular clusters); gray squares indicate other MDR MTBC isolates. All analyzed strains belong to the major MTBC phylogenetic lineage 4 (Euro-American) or lineage 2 (Beijing); red text indicates lineage 4

Figure 1. Maximum-likelihood phylogeny, applying a general time-reversible substitution model, of 103 multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) isolates from Serbia sampled during 2008–2014. Orange squares indicate MDR MTBC isolates associated with putative transmission chains (molecular clusters); gray squares indicate other MDR MTBC isolates. All analyzed strains belong to the major MTBC phylogenetic lineage 4 (Euro-American) or lineage 2 (Beijing); red text indicates lineage 4 and blue text, lineage 2. Subgroups are further named according to the single-nucleotide polymorphism barcode nomenclature from Coll et al. (5), and to the associated mycobacterial interspersed repetitive unit–variable-number tandem-repeat genotype classification (6). Subgroup-defining branches are labeled with bootstrap values based on 1,000 resamples.

Main Article

References
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1These authors contributed equally to this article.

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