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Volume 25, Number 4—April 2019
CME ACTIVITY - Synopsis

Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017

Nguyen Vu Trung, Le Thi Hoi, Vu Minh Dien, Dang Thi Huong, Tran Mai Hoa, Vu Ngoc Lien, Phan Van Luan, Sonia Odette Lewycka, Marc Choisy, Juliet E. Bryant, Behzad Nadjm, H. Rogier van Doorn, Allen L. RichardsComments to Author , and Nguyen Van Kinh
Author affiliations: National Hospital for Tropical Diseases, Hanoi, Vietnam (N.V. Trung, L.T. Hoi, V.M. Dien, D.T. Huong, T.M. Hoa, V.N. Lien, N.V. Kinh); Hanoi Medical University, Hanoi (N.V. Trung, L.T. Hoi, P.V. Luan, N.V. Kinh); Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi (S.O. Lewycka, M. Choisy, J.E. Bryant, B. Nadjm, H.R. van Doorn); University of Oxford, UK (S.O. Lewycka, B. Nadjm, H.R. van Doorn); Institute of Research for Development, Marseille, France (M. Choisy); Merieux Foundation, Lyon, France (J.E. Bryant); Naval Medical Research Center, Silver Spring, Maryland, USA (A.L. Richards); Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA (A.L. Richards)

Main Article

Table 2

Comparison of signs and symptoms for patients with scrub typhus from Hanoi Province with patients from other provinces, northern Vietnam, March 2015–March 2017*

Sign or symptom p value
Noncorrected Corrected
Headache 0.7041 0.9071
Myalgia 0.8773 0.9071
Eye pain 0.7745 0.9071
Nausea 0.7295 0.9071
Vomiting 0.5109 0.9071
Diarrhea 0.8530 0.9071
Abdominal pain 0.2053 0.6676
Throat pain 0.8128 0.9071
Cough 0.0158 0.2194
Rash 0.8683 0.9071
Eschar 0.0219 0.2194
Skin hyperemia 0.3239 0.8098
Congestive conjuctiva 0.9071 0.9071
Lymphadenopathy 0.0590 0.3479
Edema 0.0696 0.3479
Rales 0.6423 0.9071
Resonance from lungs 0.5542 0.9071
Liver enlargement 0.2089 0.6676
Spleen enlargement 0.5725 0.9071
Convulsions 0.2336 0.6676

*n = 115; results use Fisher exact test, expressed in p values and corrected using multiple comparisons and the Benjamini and Hochberg method (20).

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Page created: March 16, 2019
Page updated: March 16, 2019
Page reviewed: March 16, 2019
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