Early Genomic Detection of Cosmopolitan Genotype of Dengue Virus Serotype 2, Angola, 2018
Sarah C. Hill, Jocelyne Neto de Vasconcelos, Bernardo Gutierrez Granja, Julien Thézé, Domingos Jandondo, Zoraima Neto, Marinela Mirandela, Cruz dos Santos Sebastião, Ana Luísa Micolo Cândido, Carina Clemente, Sara Pereira da Silva, Túlio de Oliveira, Oliver G. Pybus, Nuno R. Faria
, and Joana Morais Afonso
Author affiliations: University of Oxford, Oxford, United Kingdom (S.C. Hill, B. Gutierrez Granja, J. Thézé, O.G. Pybus, N.R. Faria); Instituto Nacional de Investigação em Saúde, Luanda, Angola (J. Neto de Vasconcelos, D. Jandondo, Z. Neto, M. Mirandela, C. dos Santos Sebastião, A.L.M. Cândido, J.M. Afonso); Universidad San Francisco de Quito, Colegio de Ciencias Biológicas y Ambientales, Quito, Ecuador (B. Gutierrez Granja); Cligest, Luanda (C. Clemente, S.P. da Silva); University of KwaZulu-Natal, Durban, South Africa (T. de Oliveira)
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Figure
Figure. Investigation of DENV infections in Luanda, Angola, January 1, 2016–May 15, 2018. A) Number of DENV infections (i.e., cases positive for DENV NS1), Luanda, Angola, May 1, 2017–May 15, 2018. B) Midpoint rooted maximum-likelihood phylogeny of DENV-2 whole genomes. Support for branching structure is shown by bootstrap values at nodes. On the right side, the cosmopolitan genotype clade containing the Angola DENV-2 sequence is expanded. Colors indicate geographic location of sampling. The Angola DENV-2 is shown in bold. Support for branching structure is shown by bootstrap values at nodes (bootstrap scores >70 shown). C) Geographic distribution of available DENV-2 sequence data (>100 bp). Pie chart radii are log-proportional to the number of sequences available in each country and are colored according to genotype DENV, dengue virus; DENV-2, dengue virus serotype 2; NS1, nonstructural protein 1; SE, Southeast; seq, sequences; und, undefined.
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