Volume 25, Number 4—April 2019
Dispatch
Prolonged Shedding of Zika Virus RNA in Vaginal Secretions, Nicaragua
Table
Clinical characteristics and viral shedding in 5 women with acute Zika virus infection, Nicaragua, 2016–2017*
Characteristic | A013 | A018 | A020 | A024 | A039 |
---|---|---|---|---|---|
Age, y | 54 | 18 | 25 | 19 | 25 |
Duration of symptoms at enrollment, d | 1 | 3 | 4 | 6 | 5 |
Pregnant at enrollment | No | Yes | Yes | Yes | Yes |
Estimated gestational age at enrollment, mo | NA | 7 | 7 | 5 | 1 |
Timing of delivery, days after symptom onset | NA | 39 | 61 | 149 | 305 |
Hematocrit, %, reference range 36–45 | 36 | 32 | 35 | 37 | 40 |
Leukocytes, cells/mm3, reference range 5,000–10,000 | 4,230 | 5,410 | 3,510 | 17,430 | 8,050 |
Sexual contact in the last 3 mo† | No | Yes | Yes | Yes | Yes |
Previous infection with dengue virus† | Yes | No | No | No | No |
Previous infection with chikungunya virus† | Yes | Yes | No | No | Yes |
Fluid Zika-positive by qRT-PCR at baseline |
Saliva |
Blood, urine |
Blood |
Urine |
Blood, saliva |
Vaginal fluid PCR results, Ct1/Ct2,‡ at approximate days after symptom onset | |||||
7 | NS | NS | NS | 0/0 | 0/0 |
14 | NS | 31/0 | 32/33 | NS | 0/0 |
21 | NS | 35/0 | 34/36 | 0/0 | 37/0 |
28 | 33/0 | 0/0 | NS | 0/0 | NS |
60 | NS | 34/36 | NS | 36/0 | NS |
90 | NS | 35/0 | NS | 0/0 | NS |
180 | NS | 37/0 | 0/0 | NS | NS |
*Ct, cycle threshold; NA, not applicable; NS, no sample; qRT-PCR, quantitative reverse transcription PCR.
†By participant report.
‡Ct1 refers to pan-Zika primers; Ct2 refers to Asian-specific primers.
1These authors contributed equally to this article.