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Volume 25, Number 7—July 2019
Research Letter

Identification of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain FC428, China

Shao-Chun Chen, Yan Han, Liu-Feng Yuan, Xiao-Yu Zhu, and Yue-Ping YinComments to Author 
Author affiliations: Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China (S.-C. Chen, Y. Han, X.-Y. Zhu, Y.-P. Yin); Chinese Center for Disease Control and Prevention, Nanjing (S.-C. Chen, Y. Han, X-.Y. Zhu, Y.-P. Yin); Beijing Ditan Hospital Capital Medical University, Beijing, China (L.-F. Yuan)

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Table

Antimicrobial susceptibility and molecular characteristics of ceftriaxone-resistant Neisseria gonorrhoeae, China*

Strains Year Country (reference) Sexual contact history MIC, mg/L
 MLST porB tbpB NG-MAST penA NG-STAR
TET SPT CRO CIP AZI CEF
Japan-FC428 2015 Japan (6) NA 0.5 8 0.5 >32 0.25 1 1903 1053 21 3435 60 233
Japan-FC460 2015 Japan (6) NA 0.5 8 0.5 >32 0.25 1 1903 1053 21 3435 60 233
China-BJ16148 2016 Aug China (this study) China 4 16 0.5 >32 0.25 1 1903 1053 21 3435 60 233
Denmark-GK124 2017 Jan Denmark (7) Denmark, China, Australia NA 8 0.5 >32 0.5 1 1903 1053 33 1614 60 233
Canada-47707 2017 Jan Canada (8) China, Thailand 4 16 1 >32 0.5 2 1903 1053 33 1614 60 233
Australia-A7846 2017 Apr Australia (9) Cambodia, Philippines 2 8 0.5 >32 0.25 NA 1903 1053 33 1614 60 233
Australia-A7536 2017 Aug Australia (9) China 4 8 0.5 >32 0.25 NA 1903 9300 21 15925 60 233

*AZI, azithromycin; CEF, cefixime; CIP, ciprofloxacin; CRO, ceftriaxone; MLST, multilocus sequence typing; NA, not available; NG-MAST, N. gonorrhoeae multiantigen sequence typing; NG-STAR, N. gonorrhoeae sequence typing for antimicrobial resistance; SPT, spectinomycin; TET, tetracycline.

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References
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