Volume 25, Number 8—August 2019
Dispatch
Efficacy of High-Dose Albendazole with Ivermectin for Treating Imported Loiasis, Italy
Federico Gobbi
, Dora Buonfrate, Francesca Tamarozzi, Monica Degani, Andrea Angheben, and Zeno Bisoffi
, Dora Buonfrate, Francesca Tamarozzi, Monica Degani, Andrea Angheben, and Zeno Bisoffi
Table
Clinical and laboratory characteristics of 16 patients with imported loiasis treated with albendazole and ivermectin, Italy, 1993–2016*
| Pt no. | Age, y/sex | Status | Place of infection | Year of diagnosis | Calabar swelling | EOS/µL | Antifilarial antibodies, OD* | MFF/ mL | Co-infections | Other treatments | Follow-up period |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
64/M |
E |
CAR |
2005 |
Yes |
4,650 |
5.06 |
Neg |
Giardiasis, strongyloidiasis |
Tinidazole |
12 y |
| 2 |
28/F |
E |
Gabon |
2008 |
Yes |
3,300 |
4.79 |
Neg |
None |
None |
10 y |
| 3 |
56/M |
E |
Chad |
2008 |
No |
4,500 |
4.22 |
270 |
Amebiasis |
Tinidazole, paromomycin |
4 y |
| 4 |
28/F |
M |
Angola |
2010 |
No |
790 |
None |
263 |
None |
None |
14 mo |
| 5 |
58/M |
E |
CAR |
2010 |
Yes |
9,320 |
1.74 |
Neg |
None |
None |
8 y |
| 6 |
52/M |
E |
Cameroon |
2010 |
Yes |
2,940 |
5.10 |
1 |
None |
None |
8 y |
| 7 |
55/M |
E |
DRC |
2011 |
Yes |
2,040 |
5.21 |
9 |
None |
None |
7 y |
| 8 |
49/M |
E |
Congo |
2014 |
Yes |
4,930 |
4.31 |
Neg |
None |
None |
4 y |
| 9 |
67/F |
E |
Nigeria |
2014 |
Yes |
13,100 |
4.05 |
Neg |
Schistosomiasis, strongyloidiasis |
Praziquantel |
4 y |
| 10 |
69/M |
E |
Cameroon |
2015 |
Yes |
1,620 |
2.19 |
152 |
None |
None |
3 y |
| 11† |
24/M |
M |
Nigeria |
2015 |
No |
1,300 |
2.16 |
160 |
Hookworm, latent tuberculosis |
DEC |
26 mo |
| 12‡ |
27/M |
M |
Cameroon |
2015 |
No |
700 |
1.53 |
491 |
Hookworm, schistosomiasis |
Praziquantel |
26 mo |
| 13 |
75/M |
E |
Cameroon |
2015 |
Yes |
4,100 |
2.85 |
Neg |
None |
None |
18 mo |
| 14 |
29/M |
M |
Cameroon |
2016 |
No |
590 |
2.85 |
990 |
Hookworm, schistosomiasis, HMS |
Praziquantel, atovaquone/ proguanile |
19 mo |
| 15 |
22/M |
M |
Cameroon |
2016 |
No |
500 |
1.39 |
9,800 |
Schistosomiasis, Mansonellosis perstans, chronic HBV |
Praziquantel, mebendazole |
18 mo |
| 16 | 18/M | M | Nigeria | 2016 | No | 1,200 | 2.52 | 477 | Hookworm | None | 16 mo |
*CAR, Central African Republic; DEC, diethylcarbamazine; DRC, Democratic Republic of the Congo; E, expatriate; EOS, eosinophils; HBV, hepatitis B virus; HMS, hyperreactive malarial splenomegaly; M, migrant; MFF, microfilariae; Neg, negative; OD, optical density; Pos, positive: Pt, patient.
*OD test is positive at ≥1 s.
†Patient with failure of albendazole and ivermectin treatment.
‡Received 1 additional course of ivermectin.
Page created: July 16, 2019
Page updated: July 16, 2019
Page reviewed: July 16, 2019
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