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Volume 26, Number 1—January 2020
Dispatch

Locally Acquired Human Infection with Swine-Origin Influenza A(H3N2) Variant Virus, Australia, 2018

Yi-Mo DengComments to Author , Frank Y.K. Wong, Natalie Spirason, Matthew Kaye, Rebecca Beazley, Migue L.l Grau, Songhua Shan, Vittoria Stevens, Kanta Subbarao, Sheena Sullivan, Ian G. Barr, and Vijaykrishna DhanasekaranComments to Author 
Author affiliations: World Health Organization Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia (Y.-M. Deng, N. Spirason, M. Kaye, K. Subbarao, S. Sullivan, I.G. Barr, V. Dhanasekaran); CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia (F.Y.K. Wong, S. Shan, V. Stevens); South Australian Department of Health and Wellbeing, Adelaide, South Australia, Australia (R. Beazley); Monash University, Melbourne (M.L. Grau, V. Dhanasekaran); University of Melbourne, Melbourne (S. Sullivan, I.G. Barr)

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Figure 2

Maximum-clade credibility tree showing the time of emergence from humans and divergence of swine influenza A and influenza A(H1N1)pdm09 virus among swine populations in Australia. Numbers 1–10 denote inferences of individual introductions from humans to swine, and virus names are colored by state of collection: red, New South Wales; blue, Queensland; green, Victoria; purple, Western Australia. Time-scaled phylogenies were estimated by using the uncorrelated log-normal relaxed clock model (11) in

Figure 2. Maximum-clade credibility tree showing the time of emergence from humans and divergence of swine influenza A and influenza A(H1N1)pdm09 virus among swine populations in Australia. Numbers 1–10 denote inferences of individual introductions from humans to swine, and virus names are colored by state of collection: red, New South Wales; blue, Queensland; green, Victoria; purple, Western Australia. Time-scaled phylogenies were estimated by using the uncorrelated log-normal relaxed clock model (11) in a Bayesian Markov chain Monte Carlo framework in BEAST version 1.10 (https://beast.community). HA, hemagglutinin.

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References
  1. Smith  GJ, Vijaykrishna  D, Bahl  J, Lycett  SJ, Worobey  M, Pybus  OG, et al. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature. 2009;459:1122–5. DOIPubMed
  2. Dawood  FS, Jain  S, Finelli  L, Shaw  MW, Lindstrom  S, Garten  RJ, et al.; Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009;360:2605–15. DOIPubMed
  3. Vincent  A, Awada  L, Brown  I, Chen  H, Claes  F, Dauphin  G, et al. Review of influenza A virus in swine worldwide: a call for increased surveillance and research. Zoonoses Public Health. 2014;61:4–17. DOIPubMed
  4. Bowman  AS, Nelson  SW, Page  SL, Nolting  JM, Killian  ML, Sreevatsan  S, et al. Swine-to-human transmission of influenza A(H3N2) virus at agricultural fairs, Ohio, USA, 2012. Emerg Infect Dis. 2014;20:1472–80. DOIPubMed
  5. Centers for Disease Control and Prevention (CDC). Influenza A (H3N2) variant virus-related hospitalizations: Ohio, 2012. MMWR Morb Mortal Wkly Rep. 2012;61:764–7.PubMed
  6. Wong  FYK, Donato  C, Deng  YM, Teng  D, Komadina  N, Baas  C, et al. Divergent human-origin influenza viruses detected in Australian swine populations. J Virol. 2018;92:e00316–8. DOIPubMed
  7. Matrosovich  M, Matrosovich  T, Carr  J, Roberts  NA, Klenk  HD. Overexpression of the alpha-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors. J Virol. 2003;77:8418–25. DOIPubMed
  8. Hayden  FG, Hay  AJ. Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine. Curr Top Microbiol Immunol. 1992;176:119–30. DOIPubMed
  9. Deng  YM, Iannello  P, Smith  I, Watson  J, Barr  IG, Daniels  P, et al. Transmission of influenza A(H1N1) 2009 pandemic viruses in Australian swine. Influenza Other Respir Viruses. 2012;6:e42–7. DOIPubMed
  10. Stamatakis  A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics. 2014;30:1312–3. DOIPubMed
  11. Drummond  AJ, Ho  SY, Phillips  MJ, Rambaut  A. Relaxed phylogenetics and dating with confidence. PLoS Biol. 2006;4:e88. DOIPubMed
  12. Duwell  MM, Blythe  D, Radebaugh  MW, Kough  EM, Bachaus  B, Crum  DA, et al. Influenza A(H3N2) variant virus outbreak at three fairs —Maryland, 2017. MMWR Morb Mortal Wkly Rep. 2018;67:1169–73. DOIPubMed
  13. Epperson  S, Jhung  M, Richards  S, Quinlisk  P, Ball  L, Moll  M, et al.; Influenza A (H3N2)v Virus Investigation Team. Human infections with influenza A(H3N2) variant virus in the United States, 2011-2012. Clin Infect Dis. 2013;57(Suppl 1):S4–11. DOIPubMed
  14. Jhung  MA, Epperson  S, Biggerstaff  M, Allen  D, Balish  A, Barnes  N, et al. Outbreak of variant influenza A(H3N2) virus in the United States. Clin Infect Dis. 2013;57:1703–12. DOIPubMed
  15. Animal Health Australia. AUSVETPLAN manuals and documents. Influenza A viruses in swine (Version 4.0) [cited 2019 Jul 5]. https://www.animalhealthaustralia.com.au/our-publications/ausvetplan-manuals-and-documents

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Page created: December 18, 2019
Page updated: December 18, 2019
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