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Volume 26, Number 1—January 2020
Research Letter

Imported Schistosomiasis, China, 2010–2018

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Si-Min Dai, Zhou Guan, Li-Juan Zhang, Shan Lv, Chun-Li Cao, Shi-Zhu Li, and Jing XuComments to Author 
Author affiliations: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China; World Health Organization Collaborating Centre for Tropical Diseases, Shanghai; National Tropical Disease Research Center, Shanghai

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Abstract

China has made remarkable progress in reducing schistosomiasis caused by Schistosoma japonicum over the past 7 decades but now faces a severe threat from imported schistosomiasis. Results from national surveillance during 2010–2018 indicate integrating active surveillance into current surveillance models for imported cases is urgently needed to achieve schistosomiasis elimination in China.

Six species of Schistosoma trematodes are known to infect humans, but only S. japonicum is prevalent in China (1,2). However, because of enhanced international cooperation and communication, 2 Schistosoma species were identified from schistosomiasis cases imported to China: S. haematobium and S. mansoni. In addition, the Biomphalaria straminea snail, an intermediate host of S. mansoni trematodes, has been introduced into Shenzhen, Guangdong Province (3,4), so the possibility exists that imported S. mansoni trematodes could be transmitted to these snails and result in locally acquired human infections. Therefore, we analyzed imported schistosomiasis status in China through data collected from the National Notifiable Disease Report System (NNDRS) during 2010–2018 to provide information for national policy making on schistosomiasis elimination.

We defined imported schistosomiasis as schistosomiasis in an endemic focus outside mainland China. A confirmed imported case had to meet both of the following diagnostic criteria: the patient was given a diagnosis of schistosomiasis, meaning that schistosome eggs or miracidia were detected in the patient’s biological samples; the patient once traveled to and/or worked in schistosomiasis-endemic areas in other countries during transmission seasons (Table).

Twenty-two cases were reported during the study period. All imported cases occurred in men; their ages ranged from 30 to 68 years (mean 48 ± SD 9.98 years). Nineteen (86%) were 30–58 years of age, and 3 (14%) were >58 years of age. Half of them were workers who returned to China from Africa; 4 (18%) were businessmen. No case was reported in Guangdong Province; 4 cases were reported in the neighboring provinces of Guangxi, Jiangxi, and Fujian.

The 22 cases acquired Schistosoma infection in 8 countries in Africa. Of the 20 case-patients for whom detailed data were available, most were infected in central Africa (Angola, 6 [30%] cases) and Cameroon and Congo (1 [5%] case each). In West Africa, Nigeria accounted for 6 (30%) cases and Mali for 1 (5%) case; in southern Africa, Zambia accounted for 4 (20%) cases.

More than 1 million persons from China are estimated to work in Africa (5). However, during the study period, only 22 confirmed cases were recognized. Considering the high risk for infection in Africa and the existing passive surveillance system, the number of imported schistosomiasis cases might be substantially underestimated.

As a national schistosomiasis surveillance system in China, NNDRS mirrors the local and imported case status passively reported on a national scale: when patients exposed in Africa had symptoms after returning to China, they sought treatment at hospitals on their own. If schistosomiasis was confirmed, the physician reported it to NNDRS, the only case report source in the existing surveillance system. However, this surveillance model has limitations. For example, cases might be misdiagnosed and missed because medical staff have insufficient clinical awareness of African schistosomiasis or because some patients may be asymptomatic or have mild symptoms.

Another challenge is that global integration has contributed to an increasing number of persons from China who travel abroad, and most persons who travel to Africa are not equipped with essential knowledge about schistosomiasis prevention and control. In addition, introduction of the B. straminea snail into southern China increases the risk that persons in China might acquire S. mansoni infection.

Because imported schistosomiasis may increase the disease burden in China and hinder the process of schistosomiasis elimination, several measures are urgently needed. First, a well-rounded active surveillance system needs to be integrated into the current monitoring model to ensure an accurate and quick response. When performing active surveillance through screening, sensitive and rapid immunologic tests should be widely conducted among the most susceptible group before etiologic examinations are conducted. Our results suggest that male workers returning from Africa are the most susceptible population. Meanwhile, because the intermediate host of African schistosomiasis, the B. straminea snail, has been introduced to Guangdong Province in southern China, persons returning from S. mansoni–endemic countries or regions. Guangdong Province and adjacent provinces should be a primary target population for surveillance. Identifying migrant workers as the highest priority group for active surveillance will be of great value. Second, China should collaborate with the World Health Organization and other relevant international institutions to evaluate the feasibility of existing serologic detection kits developed by China for diagnosis of imported schistosomiasis or develop new kits if necessary. Third, training programs on standardized clinical diagnostic criteria and normative case reporting operation are required in different types of healthcare organizations (e.g., hospitals, Centers for Disease Control and Prevention, entry and exit border stations) in mainland China to ensure accurate diagnosis and disease treatment. Other measures, such as multisector cooperation and coordination, could help achieve elimination of schistosomiasis in China.

Miss Dai is a junior researcher in the National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China. Her research interests include tropical diseases and epidemiology.

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Acknowledgment

This study was financially supported by the National Science and Technology Major Project (no. 2018ZX10101002-002, 2016YFC1202000).

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References

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  2. McManus  DP, Dunne  DW, Sacko  M, Utzinger  J, Vennervald  BJ, Zhou  XN. Schistosomiasis. Nat Rev Dis Primers. 2018;4:13. DOIPubMed
  3. Meier-Brook  C. A snail intermediate host of Schistosoma mansoni introduced into Hong Kong. Bull World Health Organ. 1974;51:661.PubMed
  4. Habib  MR, Lv  S, Guo  YH, Gu  WB, Standley  CJ, Caldeira  RL, et al. Morphological and molecular characterization of invasive Biomphalaria straminea in southern China. Infect Dis Poverty. 2018;7:120. DOIPubMed
  5. Wang  ZQ, Wang  Y, Jia  LJ, Cui  J. Schistosoma haematobium infection in workers returning from Africa to China. J Travel Med. 2013;20:2568. DOIPubMed

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Cite This Article

DOI: 10.3201/eid2601.191250

Original Publication Date: December 10, 2019

Table of Contents – Volume 26, Number 1—January 2020

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Jing Xu, Chinese Center for Disease Control and Prevention, National Institute of Parasitic Diseases; WHO Collaborating Centre for Tropical Diseases, National Tropical Disease Research Center, 207 Rui Jin Rd, Shanghai 200025, China

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Page created: December 18, 2019
Page updated: December 18, 2019
Page reviewed: December 18, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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