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Volume 26, Number 10—October 2020
Research Letter

Macrolide-Resistant Bordetella pertussis, Vietnam, 2016−2017

Kazunari Kamachi1Comments to Author , Hong T. Duong, Anh D. Dang, T. Hai, Do Do, Kentaro Koide, Nao Otsuka, Keigo Shibayama, and Ha Thi Thu Hoang1
Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (K. Kamachi, K. Koide, N. Otsuka, K. Shibayama); National Institute of Hygiene and Epidemiology, Hanoi, Vietnam (H.T. Duong, A.D. Dang, H.T.T. Hoang); Center for Pediatric Tropical Diseases, National Hospital of Pediatrics, Hanoi (H.T. Do)

Main Article

Table

Direct genotyping of Bordetella pertussis with the detected macrolide-resistant A2047G mutation in the 23S rRNA gene, Vietnam, 2016−2017*

Patient no. Age/sex Year/province MLVA type Repeat no. VNTRs† Allele type of virulence-associated genes‡
 C5330 in fhaB§
ptxP ptxA prn fim3
1 2.5 mo/M 2016/Hanoi MT104 8/6/0/7/6/10 1 1 1 A NA
2 2 mo/F 2016/Ha Nam New type A 8/6/0/6/6/10 1 1 1 A C5330T
3 32 d/F 2016/Hanoi New type B 9/6/0/7/6/10 1 1 1 A C5330T
4 3 mo/F 2016/Hanoi MT104 8/6/0/7/6/10 1 1 1 A C5330T
5 2 mo/M 2016/Hanoi MT104 8/6/0/7/6/10 1 1 1 A C5330T
6 29 y/F 2016/Hanoi MT104 8/6/0/7/6/10 1 1 1 B C5330T
7 4 mo/F 2017/Thai Binh MT104 8/6/0/7/6/10 NA 1 1 B C5330T
8 52 d/F 2017/Ha Nam MT104 8/6/0/7/6/10 1 1 1 A C5330T
9 3 mo/M 2017/Hanoi MT104 8/6/0/7/6/10 1 1 1 A C5330T
10 3 mo/M 2017/Hanoi MT104 8/6/0/7/6/10 1 1 1 A C5330T

*MLVA, multilocus variable-number tandem-repeat analysis; NA, not analyzed; VNTR, variable-number tandem-repeat.
†The order is VNTR1/VNTR3a/VNTR3b/VNTR4/VNTR5/VNTR6.
‡B. pertussis virulence–associated allelic genes (ptxP, ptxA, prn, and fim3).
§fhaB3 allele carries the single-nucleotide polymorphism mutation C5330T.

Main Article

1These authors contributed equally to this article.

Page created: September 07, 2020
Page updated: September 17, 2020
Page reviewed: September 17, 2020
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