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Volume 26, Number 11—November 2020

Streptococcus pneumoniae Serotype 12F-CC4846 and Invasive Pneumococcal Disease after Introduction of 13-Valent Pneumococcal Conjugate Vaccine, Japan, 2015–2017

Satoshi NakanoComments to Author , Takao Fujisawa, Yutaka Ito, Bin Chang, Yasufumi Matsumura, Masaki Yamamoto, Shigeru Suga, Makoto Ohnishi, and Miki Nagao
Author affiliations: Kyoto University Graduate School of Medicine, Kyoto, Japan (S. Nakano, Y. Matsumura, M. Yamamoto, M. Nagao); National Hospital Organization Mie National Hospital, Tsu, Japan (T. Fujisawa, S. Suga); Nagoya City University Graduate School of Medical Science, Nagoya, Japan (Y. Ito); National Institute of Infectious Diseases, Tokyo, Japan (B. Chang, M. Ohnishi)

Main Article


Antimicrobial susceptibilities of Streptococcus pneumoniae serotype 12F isolates recovered in Japan, 2017*

Sequence type No. isolates MIC, μg/mL
<0.06 0.12 0.25 <0.06 0.12 0.25 <0.06 <0.06 >128 0.5 1
4846 59 16 42 1 54 3 2 59 0 59 4 55
6945 16 15 1 0 16 0 0 16 3 13 0 16

*Susceptibility categories were based on Clinical and Laboratory Standard 2015 antimicrobial susceptibility testing standards for S. pneumoniae (10). If categories for meningitis are available, they are shown. The standards are penicillin <0.06 susceptible, >0.12 resistant; cefotaxime <0.5 susceptible, 1.0 intermediate, >2 resistant; meropenem <0.25 susceptible, 0.5 intermediate, >1.0 resistant; erythromycin <0.25 susceptible, 0.5 intermediate, >1.0 resistant; levofloxacin <2.0 susceptible, 4.0 intermediate, >8.0 resistant.

Main Article

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