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Volume 26, Number 12—December 2020
Dispatch

Direct Transmission of Severe Fever with Thrombocytopenia Syndrome Virus from Domestic Cat to Veterinary Personnel

Atsushi Yamanaka, Yumi Kirino, Sho Fujimoto, Naoyasu Ueda, Daisuke Himeji, Miho Miura, Putu E. Sudaryatma, Yukiko Sato, Hidenori Tanaka, Hirohisa Mekata, and Tamaki OkabayashiComments to Author 
Author affiliations: Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan (A. Yamanaka, S. Fujimoto, N. Ueda, D. Himeji); University of Miyazaki, Miyazaki (Y. Kirino, P.E. Sudaryatma, Y. Sato, H. Tanaka, H. Mekata, T. Okabayashi); Miyazaki Prefectural Institute for Public Health and Environment, Miyazaki (M. Miura)

Main Article

Table

Hematologic and diagnostic results from a nosocomial outbreak of infection with severe fever with thrombocytopenia syndrome virus in animal hospital, Japan, 2018*

Characteristic Cat,† Aug 15 Patient 1
 Patient 2
Aug 27 Aug 28 Aug 29 Aug 30 Sep 5 Sep 11 Aug 28 Sep 11
RT-PCR + − − + + ND ND + ND
Virus-specific IgG + − − ND − ND + − +
Real-time RT-PCR, copies/mL 1.5 × 1011 ND ND 3.9 × 106 6.0 × 106 ND ND 5.7 × 106 ND
Isolation‡ J1 ND ND J1 J1 ND ND J1 ND
Leukocytes/μL 1, 080 (4–30 x 103) 1,970 1,300 1,060 1,450 2,570 4,070 2,850 4,630
Hemoglobin, g/dL 14.6 (9–18) 13.1 12.6 12.3 13.4 11.6 12.6 13.4 13.1
Platelet count/μL 19,000 (9–90 x 104) 81,000 63,000 53,000 59,000 155,000 214,000 254,000 261,000
Total bilirubin, mg/dL 3.1 (0–0.5) 0.36 0.26 ND 0.28 0.44 0.69 0.44 0.42
AST, IU/L ND 18 17 20 27 51 11 25 24
ALT, IU/L 91 (47.4–97.3) 12 10 12 16 60 25 37 28
LDH, IU/L ND 134 123 149 157 130 156 213 267
C-reactive protein, mg/dL ND 0.04 0.04 ND 0.03 0.01 0.002 0.17 0.19

*ALT, alanine aminotransferase; AST, aspartate aminotransferase; J1, J1 genotype; LDH, lactate dehydrogenase; ND, not done; RT-PCR, reverse transcription PCR; –, negative; +, positive.
†Values in parentheses are standard feline hematologic parameters reported by O’Brien et al. (12).
‡Virus isolated on Vero cells and genotyping.

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References
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Page created: July 13, 2020
Page updated: November 19, 2020
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