Table 3

Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016¹

Gisele Peirano², Tarah Lynch², Yasufumi Matsumara², Diego Nobrega, Thomas J. Finn, Rebekah DeVinney, and Johann D.D. Pitout

Author affiliations: University of Calgary Cummings School of Medicine, Calgary, Alberta, Canada (G. Peirano, T. Lynch, T.J. Finn, R. De Vinney, J.D.D. Pitout); Alberta Precision Laboratories, Calgary (G. Peirano, T. Lynch, J.D.D. Pitout); Kyoto University Graduate School of Medicine, Kyoto, Japan (Y. Matsumara); University of Calgary, Calgary (D. Nobrega); University of Pretoria, Pretoria, South Africa (J.D.D. Pitout)

Main Article

Factors associated with Escherichia coli sequence type 131 clades, Calgary, Alberta, Canada, 2006, 2012, and 2016*

Factor	Clade
Factor	A, n = 34	B, n = 32	C0, n = 5	C1-non-M27, n = 121	C1-M27, n = 13	C2, n = 139	All, n = 344
QRDR mutation
gyrA S83L	29 (85)^a,b	2 (6)^c	2 (40)^b,c	121 (100)^d	13 (100)^a,d	139 (100)^d	306 (89)
gyrA D87N	5 (15)^a	0^a	1 (20)^a	121 (100)^b	13 (100)^b	139 (100)^b	279 (8)
parC S80I	5 (15)^a	2 (6)^a	1 (20)^a	121 (100)^b	13 (100)^b	139 (100)^b	281 (82)
parC E84V	1 (3)^a	0^a	1 (20)^a	121 (100)^b	13 (100)^b	139 (100)^b	275 (80)
parE I529L	30 (88)^a	27 (84)^a	5 (100)	121 (100)^b	13 (100)	139 (100)^b	335 (97)
β-lactamase
CTX-M-15	2 (6)^a	1 (3)^a	0^a	1 (1)^a	0^a	93 (67)^b	97 (28)
CTX-M-14	0^a	0^a	0	38 (31)^b	0	1 (1)^a	39 (11)
CTX-M-27	1 (3)^a	0^a	0	0^a	7 (54)^b	0^a	8 (2)
CTX-M-55	2 (6)	0	0	0	0	0	2 (0.6)
CTX-M-198	0	0	0	1 (1)	0	0	1 (0.3)
NDM-5	0	0	0	0	0	1 (1)	1 (0.3)
OXA-1	0^a	0^a	0^a	1 (1)^a	0^a	84 (6)^b	85 (25)
OXA-9	0	0	0	0	0	1 (1)	1 (0.3)
SHV-12	0	0	0	0	0	2 (1)	2 (0.6)
TEM-1	29 (85)^a,b	20 (63)^a	4 (80)^a,b	103 (85)^b	1 (8)^c	26 (19)^c	183 (53)
TEM other	0	0	0	2 (2)	0	2 (1)	4 (1)
CMY-2	0	2 (6%)	0	1 (1)	0	0	3 (0.9)
Aminoglycoside-modifying enzyme
Aac(3)-IIa	0^a	0^a	0	2 (1)^a	0^a	57 (41)^b	59 (17)
Aac(3))-IId	11 (32)^a,b	15 (47)^a	0	63 (52)^a	0^b,c	4 (3)^c	93 (27)
aac(6')-Ib-cr	0^a	0^a	0^a	2 (2)^a	0^a	84 (60)^b	86 (25)
aadA1	0	2 6)	0	0	0	4 (3)	6 (2)
aadA16	0	0	0	1 (1)	0	1 (1)	2 (0.6)
aadA2	0^a	14 (44)^b	0	0^a	0^a	2 (1)^a	16 ()
aadA5	23 (68)^a	1 (3)^b	3 (60)^a,c	70 (58)^a	7 (54)^a,c	57 (41)^c	161 (47)
ant(2′′)-Ia	0	0	0	0	0	5 (4)	5 (1)
aph(3′)-Ia	1 (3)	2	0	1 (11)	0	0	4 (1)
aph(3′′)-Ib	20 (59)^a	3 (9)^b	0	69 (57)^a	5 (38)	26 (19)^b	123 (36)
aph(3′)-IIa	0	1 (3)	0	1 (1)	0	0	2 (0.6)
Aph(6)-Ic	0	1 (3)	0	1 (1)	0	0	2 (0.6)
Aph(6)-Id	20 (59)^a	3 (9)^b	0	68 (56)^a	5 (38)	25 (18)^b	121 (35)
Other
qnrB	0	0	0	0	0	2 (1)	2 (0.6)
ARR-3	0	0	0	1 (1)	0	1 (1)	2 (0.6)
dfrA1	0	1 (3)	0	0	0	0	1 (0.3)
dfrA12	0^a	13 (41)^b	0	0^a	0^a	2 (1)^a	15 (4)
dfrA14	1 (3)	0	0	0	0	8	12 (3)
dfrA17	22 (65)^a	1 (3)^b	3 (60)^a	70 (58)^a	7 (54)^a	59 (42)^a	162 (47)
dfrA27	0	0	0	1 (1)	0	1 (1)	2 (0.6)
dfrA5	0	1 (3)	0	0	0	0	1 (0.3)
sul1	22 (65)	15 (47)	3 (60)	69 (57)	6 (46)	63 (45)	178 (52)
sul2	20 (59)^a	3 (9)^b	0	70 (58)^a	5 (38)	28 (20)^b	126 (37)
sul3	0	1 (3)	0	0	0	0	1 (0.3)
tetA	19 (56)^a	5 (16)^b	0	61 (50)^a	6 (4)	77 (55)^a	168 (49)
tetB	2 (6)	3 (9)	0	2 (2)	0	3 (2)	10 (3)

*Values are no. (%). Rates followed by different superscript letters indicate significant differences between clades at the 5% level (adjusted for multiple comparisons).

Main Article

¹Accepted as an oral presentation for the 30th European Congress of Clinical Microbiology and Infectious Diseases, Paris, France, April 18–21, 2020.

²These authors contributed equally to this article.

Page created: August 05, 2020

Page updated: November 19, 2020

Page reviewed: November 19, 2020

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Volume 26, Number 12—December 2020

Research

Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–20161

Table 3

Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016¹