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Volume 26, Number 2—February 2020
Research Letter

Antigenic Variant of Highly Pathogenic Avian Influenza A(H7N9) Virus, China, 2019

Wenming Jiang, Guangyu Hou, Jinping Li, Cheng Peng, Suchun Wang, Shuo Liu, Qingye Zhuang, Liping Yuan, Xiaohui Yu, Yang Li, Jingjing Wang, and Hualei LiuComments to Author 
Author affiliations: China Animal Health and Epidemiology Center, Qingdao, China

Main Article

Table

Efficacy of H7-Re2 vaccine against highly pathogenic avian influenza A(H7N9) viruses in chickens, China, 2019*

Vaccine Challenge virus Mean HI titer 21 d after vaccination (log2)
Virus shedding
Survival rate
Postchallenge day 3
Postchallenge day 5
Challenge virus H7-Re2 Trachea Cloaca Trachea Cloaca
H7-Re2
FQ2 3.2 ± 0.6 7.7 ± 0.5 8/8 (2.6 ± 0.4) 8/8 (2.4 ± 0.3) 4/4 (2.3 ± 0.3) 4/4 (2.5 ± 0.4) 4/10
DL1
3.3 ± 0.5
7.9 ± 0.4

8/8 (2.8 ± 0.3)
8/8 (2.5 ± 0.3)

4/4 (2.2 ± 0.4)
4/4 (2.3 ± 0.3)
4/10
rFQ2
FQ2 7.6 ± 0.6 7.0 ± 0.5 0/10 0/10 0/10 0/10 10/10
DL1
7.3 ± 0.5
6.8 ± 0.4

0/10
0/10

0/10
0/10
10/10
Control FQ2 <1 <1 4/4 (4.8 ± 0.5) 4/4 (4.5 ± 0.4) NA NA 0/10
DL1 <1 <1 4/4 (4.7 ± 0.4) 4/4 (4.9 ± 0.5) NA NA 0/10

*HI, hemagglutination inhibition; NA, not applicable because of death of chickens.

Main Article

Page created: January 20, 2020
Page updated: January 20, 2020
Page reviewed: January 20, 2020
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