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Volume 26, Number 4—April 2020

Decreased Susceptibility to Azithromycin in Clinical Shigella Isolates Associated with HIV and Sexually Transmitted Bacterial Diseases, Minnesota, USA, 2012–2015

Dana EikmeierComments to Author , Pamela Talley, Anna Bowen, Fe Leano, Ginette Dobbins, Selina Jawahir, Annastasia Gross, Dawn Huspeni, Allison La Pointe, Stephanie Meyer, and Kirk Smith
Author affiliations: Minnesota Department of Health, St. Paul, Minnesota, USA (D. Eikmeier, F. Leano, G. Dobbins, S. Jawahir, A. Gross, D. Huspeni, A. La Pointe, S. Meyer, K. Smith); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P. Talley, A. Bowen)

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Table 4

Sexually transmitted diseases reported in the 12 months before Shigella specimen collection for 217 men with shigellosis, by azithromycin susceptibility status, Minnesota, USA, 2012–2015*

Disease DSA, n = 42, no. (%) Azithromycin susceptible, n = 175, no. (%) OR (95% CI)† p value
Chlamydia 13 (31) 9 (5) 8.3 (3.2–21.1) <0.001
Gonorrhea 10 (24) 10 (6) 5.2 (2.0–13.4) 0.001
Syphilis 5 (12) 2 (1) 11.7 (2.2–62.6) 0.003
HIV‡ 25 (60) 40 (23) 5.0 (2.4–10.1) <0.001
Any bacterial STD§ 20 (48) 16 (9) 9.0 (4.1–20.0) <0.001
Multiple bacterial STDs§ 9 (21) 5 (3) 9.3 (2.9–29.4) <0.001

*All Shigella infections reported in men are included. Two men who were PLWH had 2 Shigella infections, and 1 man who was PLWH had 3 Shigella infections during the study period. DSA, decreased susceptibility to azithromycin; OR, odds ratio; PLWH, persons living with HIV; STD, sexually transmitted disease.
†Reference group is men with azithromycin-susceptible Shigella.
‡HIV positive at any time before Shigella isolation.
§Chlamydia, gonorrhea, or syphilis only.

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Page created: March 17, 2020
Page updated: March 17, 2020
Page reviewed: March 17, 2020
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