Volume 26, Number 4—April 2020
Synopsis
Decreased Susceptibility to Azithromycin in Clinical Shigella Isolates Associated with HIV and Sexually Transmitted Bacterial Diseases, Minnesota, USA, 2012–2015
Table 4
Sexually transmitted diseases reported in the 12 months before Shigella specimen collection for 217 men with shigellosis, by azithromycin susceptibility status, Minnesota, USA, 2012–2015*
Disease | DSA, n = 42, no. (%) | Azithromycin susceptible, n = 175, no. (%) | OR (95% CI)† | p value |
---|---|---|---|---|
Chlamydia | 13 (31) | 9 (5) | 8.3 (3.2–21.1) | <0.001 |
Gonorrhea | 10 (24) | 10 (6) | 5.2 (2.0–13.4) | 0.001 |
Syphilis | 5 (12) | 2 (1) | 11.7 (2.2–62.6) | 0.003 |
HIV‡ | 25 (60) | 40 (23) | 5.0 (2.4–10.1) | <0.001 |
Any bacterial STD§ | 20 (48) | 16 (9) | 9.0 (4.1–20.0) | <0.001 |
Multiple bacterial STDs§ | 9 (21) | 5 (3) | 9.3 (2.9–29.4) | <0.001 |
*All Shigella infections reported in men are included. Two men who were PLWH had 2 Shigella infections, and 1 man who was PLWH had 3 Shigella infections during the study period. DSA, decreased susceptibility to azithromycin; OR, odds ratio; PLWH, persons living with HIV; STD, sexually transmitted disease.
†Reference group is men with azithromycin-susceptible Shigella.
‡HIV positive at any time before Shigella isolation.
§Chlamydia, gonorrhea, or syphilis only.