Volume 26, Number 5—May 2020
Synopsis
Clinical Outcomes of Patients Treated for Candida auris Infections in a Multisite Health System, Illinois, USA
Table 1
Antifungal drug | MIC, µg/mL |
|||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 64 | 128 | 256 | >256 | |
Anidulafungin | 3.6 | 64.3 | 28.6 | 3.6 | ||||||||||
Caspofungin | 3.6 | 25.0 | 42.9 | 25.0 | 3.6 | |||||||||
Micafungin | 50.0 | 39.3 | 3.6 | 3.6 | 3.6 | |||||||||
Fluconazole | 39.3 | 35.7 | 10.7 | 3.6 | 3.6 | 3.6 | 3.6 | |||||||
Itraconazole | 7.1 | 32.1 | 39.3 | 17.9 | 3.6 | |||||||||
Posaconazole | 10.7 | 50.0 | 25.0 | 14.3 | ||||||||||
Voriconazole | 42.9 | 21.4 | 21.4 | 3.6 | 10.7 | |||||||||
Amphotericin B | 10.7 | 82.1 | 3.6 | |||||||||||
Flucytosine | 17.9 | 71.4 | 10.7 |
*Values are percentage of isolates having the MIC shown. Shaded values are considered resistant on the basis of Centers for Disease Control and Prevention tentative C. auris breakpoints (22).
References
- Satoh K, Makimura K, Hasumi Y, Nishiyama Y, Uchida K, Yamaguchi H. Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol. 2009;53:41–4. DOIPubMedGoogle Scholar
- Lee WG, Shin JH, Uh Y, Kang MG, Kim SH, Park KH, et al. First three reported cases of nosocomial fungemia caused by Candida auris. J Clin Microbiol. 2011;49:3139–42. DOIPubMedGoogle Scholar
- Chowdhary A, Sharma C, Duggal S, Agarwal K, Prakash A, Singh PK, et al. New clonal strain of Candida auris, Delhi, India. Emerg Infect Dis. 2013;19:1670–3. DOIPubMedGoogle Scholar
- Magobo RE, Corcoran C, Seetharam S, Govender NP. Candida auris-associated candidemia, South Africa. Emerg Infect Dis. 2014;20:1250–1. DOIPubMedGoogle Scholar
- Emara M, Ahmad S, Khan Z, Joseph L, Al-Obaid I, Purohit P, et al. Candida auris candidemia in Kuwait, 2014. Emerg Infect Dis. 2015;21:1091–2. DOIPubMedGoogle Scholar
- Schelenz S, Hagen F, Rhodes JL, Abdolrasouli A, Chowdhary A, Hall A, et al. First hospital outbreak of the globally emerging Candida auris in a European hospital. Antimicrob Resist Infect Control. 2016;5:35. DOIPubMedGoogle Scholar
- Calvo B, Melo AS, Perozo-Mena A, Hernandez M, Francisco EC, Hagen F, et al. First report of Candida auris in America: Clinical and microbiological aspects of 18 episodes of candidemia. J Infect. 2016;73:369–74. DOIPubMedGoogle Scholar
- Vallabhaneni S, Kallen A, Tsay S, Chow N, Welsh R, Kerins J, et al.; MSD. Investigation of the first seven reported cases of Candida auris, a globally emerging invasive, multidrug-resistant fungus—United States, May 2013–August 2016. MMWR Morb Mortal Wkly Rep. 2016;65:1234–7. DOIPubMedGoogle Scholar
- Heath CH, Dyer JR, Pang S, Coombs GW, Gardam DJ. Candida auris sternal osteomyelitis in a man from Kenya visiting Australia, 2015. Emerg Infect Dis. 2019;25:192–4. DOIPubMedGoogle Scholar
- Adams E, Quinn M, Tsay S, Poirot E, Chaturvedi S, Southwick K, et al.; Candida auris Investigation Workgroup. Candida auris Investigation Workgroup. Candida auris in healthcare facilities, New York, USA, 2013–2017. Emerg Infect Dis. 2018;24:1816–24. DOIPubMedGoogle Scholar
- Sarma S, Upadhyay S. Current perspective on emergence, diagnosis and drug resistance in Candida auris. Infect Drug Resist. 2017;10:155–65. DOIPubMedGoogle Scholar
- Lone SA, Ahmad A. Candida auris-the growing menace to global health. Mycoses. 2019;62:620–37. DOIPubMedGoogle Scholar
- Osei Sekyere J. Candida auris: A systematic review and meta-analysis of current updates on an emerging multidrug-resistant pathogen. MicrobiologyOpen. 2018;7:
e00578 . DOIPubMedGoogle Scholar - Kerins JL, Tang AS, Forsberg K, Jegede O, Ealy M, Pacilli M, et al. Rapid emergence of Candida auris in the Chicago region. Open Forum Infect Dis. 2018;5(S1):S28. DOIGoogle Scholar
- Hayden MK, Dangana TE, Yelin RD, Schoeny M, Bell PB, Stanley M, et al. Prevalence of Candida auris at body sites, characterization of skin microbiota, and relation of chlorhexidine gluconate (CHG) skin concentration to C. auris detection among patients at a high-prevalence ventilator-capable skilled nursing facility (vSNF) with established CHG bathing. Open Forum Infect Dis. 2019;6(S2):S25–6. DOIGoogle Scholar
- Lockhart SR, Etienne KA, Vallabhaneni S, Farooqi J, Chowdhary A, Govender NP, et al. Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses. Clin Infect Dis. 2017;64:134–40. DOIPubMedGoogle Scholar
- Park JY, Bradley N, Brooks S, Burney S, Wassner C. Management of patients with Candida auris fungemia at community hospital, Brooklyn, New York, USA, 2016–2018. Emerg Infect Dis. 2019;25:601–2. DOIPubMedGoogle Scholar
- Tsay S, Welsh RM, Adams EH, Chow NA, Gade L, Berkow EL, et al.; MSD. Ongoing transmission of Candida auris in health care facilities—United States, June 2016–May 2017. MMWR Morb Mortal Wkly Rep. 2017;66:514–5. DOIPubMedGoogle Scholar
- Bajpai V, Govindaswamy A, Sagar S, Kumar S, Garg P, Xess I, et al. Multidrug-resistant fungemia in critical care units: experience from a tertiary care hospital in India. Microb Drug Resist. 2019;mdr.2019.0021 [Epub ahead of print].
- Chow NA, Gade L, Tsay SV, Forsberg K, Greenko JA, Southwick KL, et al.; US Candida auris Investigation Team. Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: a molecular epidemiological survey. Lancet Infect Dis. 2018;18:1377–84. DOIPubMedGoogle Scholar
- Biagi MJ, Wiederhold NP, Gibas C, Wickes BL, Lozano V, Bleasdale SC, et al. Development of high-level echinocandin resistance in a patient with recurrent Candida auris candidemia secondary to chronic candiduria. Open Forum Infect Dis. 2019;6:
ofz262 . DOIPubMedGoogle Scholar - Tsay S, Kallen A, Jackson BR, Chiller TM, Vallabhaneni S. Approach to the investigation and management of patients with Candida auris, an emerging multidrug‐resistant yeast. Clin Infect Dis. 2018;66:306–11. DOIPubMedGoogle Scholar
Page created: April 16, 2020
Page updated: April 16, 2020
Page reviewed: April 16, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.