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Volume 26, Number 6—June 2020

Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010–2018

Takeshi Nishijima, Kei KawanaComments to Author , Ichio Fukasawa, Naoko Ishikawa, Melanie M. Taylor, Hiroshige Mikamo, Kiyoko Kato, Jo Kitawaki, Tomoyuki Fujii, and Women’s Health Care CommitteeJapan Society of Obstetrics and Gynecology
Author affiliations: National Center for Global Health and Medicine, Tokyo, Japan (T. Nishijima); World Health Organization Regional Office of the Western Pacific, Manila, the Philippines (T. Nishijima, N. Ishikawa); Nihon University School of Medicine, Tokyo, Japan (K. Kawana); Dokkyo Medical University, Tochigi, Japan (I. Fukasawa); World Health Organization, Geneva, Switzerland (M.M. Taylor); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.M. Taylor); Aichi Medical University, Aichi, Japan (H. Mikamo); Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (K. Kato); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (J. Kitawaki); Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (T. Fujii)

Main Article

Table 4

Serologic outcomes of pregnant women with active syphilis treated with amoxicillin or ampicillin, Japan, 2010–2018, by delivery, 6 months after treatment, and 1 year after treatment*

Patient group No./total (%) with >4-fold decrement in RPR titer
By delivery 6 months after treatment 1 year after treatment
All 35/71 (49) 41/77 (53) 46/56 (82)
Live birth without CS diagnosis 27/54 (50) 29/54 (54) 31/39 (80)
CS cases† 5/13 (39) 6/15 (40) 9/11 (82)
Early syphilis 15/26 (58) 20/30 (67) 21/23 (91)
Late syphilis 20/45 (44) 21/47 (45) 25/33 (76)
Amoxicillin 27/58 (47) 32/63 (51) 36/44 (82)
Ampicillin 8/13 (62) 9/14 (64) 10/12 (83)
Japanese 34/66 (52) 39/72 (54) 44/52 (85)
Non-Japanese 1/5 (20) 2/5 (40) 2/4 (50)
Started syphilis treatment >60 days before delivery 32/55 (58) 32/55 (58) 35/43 (81)
Started syphilis treatment <60 days before delivery 0 5/17 (29) 6/8 (75)

*CS, congenital syphilis; RPR, rapid plasma reagin.
†CS cases include newborns with CS diagnoses, miscarriages, and stillbirths.

Main Article

Page created: May 18, 2020
Page updated: May 18, 2020
Page reviewed: May 18, 2020
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