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Volume 26, Number 6—June 2020
Synopsis

Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome

Taylor Kain, Patrick J. Lindsay, Neill K.J. Adhikari, Yaseen M. Arabi, Maria D. Van Kerkhove, and Robert A. FowlerComments to Author 
Author affiliations: University of Toronto, Toronto, Ontario, Canada (T. Kain, P.J. Lindsay, N.K.J. Adhikari, R.A. Fowler); Harvard University, Boston, Massachusetts, USA (P.J. Lindsay); Sunnybrook Health Sciences Center, Toronto (N.K.J. Adhikari, R.A. Fowler); King Saud Bin Abdulaziz University for Health Center, Riyadh, Saudi Arabia (Y.M. Arabi); King Abdullah International Medical Research Center, Riyadh (Y.M. Arabi); World Health Organization, Geneva, Switzerland (M.D. Van Kerkhove)

Main Article

Table 4

Summary of RoB for all single-arm intervention and cohort studies calculated using the ROBBINS-I tool in a systematic review of evidence for MERS treatment with pharmacologic and supportive therapies*

Reference Reason for RoB determination
Confounding Selection of participants Classification of interventions Deviations from intended interventions Missing outcome data Outcome measurements Selection of results reported Overall RoB
Nonrandomized, single-arm intervention study with historical comparisons
(12) Serious Low Low Low Moderate Low Moderate Serious
(13) Moderate Moderate Moderate Moderate Low Low Moderate Moderate
(14)
 Serious
 Low
 Low
 Moderate
 Low
 Low
 Moderate
 Serious
Prospective cohort study
(15) Critical Moderate Low Moderate Low Low Moderate Critical
(16)
 Serious
 Low
 Moderate
 Moderate
 Low
 Low
 Moderate
 Serious
Retrospective cohort study
(17) Moderate Low Low Moderate Low Low Moderate Moderate
(18) Moderate Low Low Moderate Low Low Moderate Moderate
(19) Critical Serious Moderate Moderate Low Low Moderate Critical
(20) Critical Moderate Moderate Moderate Low Low Moderate Critical
(21) Critical Moderate Moderate Moderate Low Low Moderate Critical
(22) Serious Moderate Moderate Moderate Low Low Moderate Serious
(23) Critical Serious Serious NI NI Low Serious Critical
(24) Moderate Low Low Low Low Low Moderate Moderate
(25) Moderate Moderate Low Moderate Low Low Moderate Moderate
(26)
 Moderate
 Low
 Low
 Moderate
 Low
 Low
 Moderate
 Moderate
Case series without evaluation of treatments
(27) NA NA NA NA NA NA NA NA
(28) NA NA NA NA NA NA NA NA
(29) NA NA NA NA NA NA NA NA
(30) NA NA NA NA NA NA NA NA
(31) NA NA NA NA NA NA NA NA

*NA, not applicable; NI, no information; RoB, risk of bias.

Main Article

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Page created: May 18, 2020
Page updated: May 18, 2020
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