Volume 26, Number 7—July 2020
Dispatch
Laboratory-Acquired Dengue Virus Infection, United States, 2018
Tyler M. Sharp, Teresa G. Fisher, Kristin Long, Garry Coulson, Freddy A. Medina, Carolyn Herzig, Mary Beth Koza, Jorge Muñoz-Jordán, Gabriela Paz-Bailey, Zack Moore, and Carl Williams
Table
Summary of diagnostic test results of serum specimens collected from a case-patient with laboratory-acquired DENV infection, United States, 2018*
| Specimen designation | Time of specimen collection† | rRT-PCR | NS1 ELISA | IgM ELISA | DENV IgG ELISA titer | Neutralizing antibody titer |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DENV-1 | DENV-2 | DENV-3 | DENV-4 | WNV | YFV | ||||||
| Baseline‡ | −1.5 y | NT | NT | NT | 1:40 | <20 | <20 | <20 | <20 | <20 | 40 |
| Acute‡ | 7 d | Neg | Pos | Pos | 1:163,840 | <80 | 160 | 640 | 640 | <80 | 160 |
| Early convalescent‡ | 28 d | NT | NT | Pos | 1:163,840 | 80 | 640 | 1280 | 320 | 40 | 80 |
| Late convalescent§ | 190 d | NT | NT | Pos | 1:40,960 | 40 | <20 | 160 | 160 | NT | NT |
*DENV, dengue virus; IgM ELISA, anti-DENV IgM antibody capture enzyme linked immunosorbent assay; NS1 ELISA, nonstructural protein 1 ELISA; NT, not tested; rRT-PCR, real-time reverse transcription PCR; WNV, West Nile virus; YFV, yellow fever virus.
†Relative to illness onset.
‡Neutralizing antibody titers obtained by 90% plaque reduction neutralization test.
§Neutralizing antibody titers obtained by recombinant microfluorescence reduction neutralization test.
Page created: April 30, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
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