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Volume 26, Number 7—July 2020

Laboratory-Acquired Dengue Virus Infection, United States, 2018

Tyler M. Sharp, Teresa G. Fisher, Kristin Long, Garry Coulson, Freddy A. Medina, Carolyn Herzig, Mary Beth Koza, Jorge Muñoz-Jordán, Gabriela Paz-Bailey, Zack Moore, and Carl WilliamsComments to Author 
Author affiliations: US Public Health Service, Rockville, Maryland, USA (T.M. Sharp); Centers for Disease Control and Prevention, San Juan, Puerto Rico, USA (T.M. Sharp, F.A. Medina, J. Jorge Muñoz-Jordán, G. Paz-Bailey); North Carolina Department of Health and Human Services, Raleigh, North Carolina, USA (T.G. Fisher, K. Long, C. Herzig, Z. Moore, C. Williams)

Main Article


Summary of diagnostic test results of serum specimens collected from a case-patient with laboratory-acquired DENV infection, United States, 2018*

Specimen designation Time of specimen collection† rRT-PCR NS1 ELISA IgM ELISA DENV IgG ELISA titer Neutralizing antibody titer
Baseline‡ −1.5 y NT NT NT 1:40 <20 <20 <20 <20 <20 40
Acute‡ 7 d Neg Pos Pos 1:163,840 <80 160 640 640 <80 160
Early convalescent‡ 28 d NT NT Pos 1:163,840 80 640 1280 320 40 80
Late convalescent§ 190 d NT NT Pos 1:40,960 40 <20 160 160 NT NT

*DENV, dengue virus; IgM ELISA, anti-DENV IgM antibody capture enzyme linked immunosorbent assay; NS1 ELISA, nonstructural protein 1 ELISA; NT, not tested; rRT-PCR, real-time reverse transcription PCR; WNV, West Nile virus; YFV, yellow fever virus.
†Relative to illness onset.
‡Neutralizing antibody titers obtained by 90% plaque reduction neutralization test.
§Neutralizing antibody titers obtained by recombinant microfluorescence reduction neutralization test.

Main Article

Page created: April 30, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.