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Volume 26, Number 9—September 2020

Polyclonal Burkholderia cepacia Complex Outbreak in Peritoneal Dialysis Patients Caused by Contaminated Aqueous Chlorhexidine

Sally C.Y. Wong1, Shuk-Ching Wong, Jonathan H.K. Chen, Rosana W.S. Poon, Derek L.L. Hung, Kelvin H.Y. Chiu, Simon Y.C. So, Wing Shan Leung, Tak Mao Chan, Desmond Y.H. Yap, Vivien W.M. Chuang, Kwok-Yung Yuen2, and Vincent C.C. Cheng2Comments to Author 
Author affiliations: Queen Mary Hospital, Hong Kong, China (S.C.Y. Wong, S.-C. Wong, J.H.K. Chen, R.W.S. Poon, D.L.L. Hung, K.H.Y. Chiu, S.Y.C. So, W.S. Leung, Vincent C.C. Cheng); The University of Hong Kong, Hong Kong (T.M. Chan, D.Y.H. Yap, K.Y. Yuen); Hospital Authority, Hong Kong (V.W.M. Chuang)

Main Article

Table 3

Exit site infection rate of various microorganisms for patients in peritoneal dialysis centers in public hospitals, Hong Kong, China*

Microorganisms causing peritoneal dialysis catheter exit site infections No. infections/1,000 patient-years
p value
Centers with routine CHX use, n = 2,530 patients Centers without routine CHX use, n = 2,030 patients
Coagulase-negative staphylococci 95.25 72.41 0.0096†
Diphtheroid bacilli 19.37 31.53 0.0128
Streptococcus species 74.70 65.02 0.2424
Methicillin-resistant Staphylococcus aureus 49.41 57.64 0.2570
Methicillin-sensitive S. aureus 62.45 70.44 0.3241
Enterobacterales‡ 95.65 86.70 0.3457
Candida species§ 21.34 25.62 0.3990

*Values are pooled data from centers with and without routine CHX use for exit site care (deduplication done per center). CHX use included 0.05% aqueous CHX and 2% and 4% CHX body wash. CHX, chlorhexidine.
†Not statistically significant after Holm-Bonferroni sequential correction (0.05/7 = 0.007).
‡Included Citrobacter freundii, Enterobacter aerogenes, Escherichia coli, Klebsiella species, Morganella species, Providencia alcalifaciens, P. rettgeri, P. stuartii, Proteus species, Raoultella ornithinolytica, R. planticola, and R. terrigena.
§Included C. holmii, C. valida, Candida species, and Pichia species.

Main Article

1Current affiliation: Queen Elizabeth Hospital, Hong Kong, China.

2These senior authors contributed equally to this article.

Page created: May 12, 2020
Page updated: August 18, 2020
Page reviewed: August 18, 2020
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