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Volume 26, Number 9—September 2020
CME ACTIVITY - Synopsis

Invasive Infections with Nannizziopsis obscura Species Complex in 9 Patients from West Africa, France, 2004–20201

Dea Garcia-HermosoComments to Author , Samia Hamane, Arnaud Fekkar, Arnaud Jabet, Blandine Denis, Martin Siguier, Guy Galeazzi, Elie Haddad, Sophie Brun, Valérie Vidal, Gilles Nevez, Rozenn Le Berre, Maud Gits-Muselli, Fanny Lanternier, and Stéphane Bretagne
Author affiliations: Institut Pasteur, Paris, France (D. Garcia-Hermoso, F. Lanternier, S. Bretagne); Hôpitaux Lariboisière–Saint-Louis-Fernand Widal, Assistance Publique–Hôpitaux de Paris, Paris (S. Hamane, A. Jabet, B. Denis, M. Siguier, M. Gits-Muselli, S. Bretagne); Groupe Hospitalier Pitié–Salpêtrière, Assistance Publique–Hôpitaux de Paris, Sorbonne Université, Paris (A. Fekkar); Hôpital Max Fourestier, Nanterre, France (G. Galeazzi); Centre Hospitalier Universitaire Hôtel-Dieu de France, Université de Saint-Joseph, Beirut, Lebanon (E. Haddad); Hôpital Avicenne, Assistance Publique–Hôpitaux de Paris, Bobigny, France (S. Brun, V. Vidal); Hôpital La Cavale Blanche, Centre Hospitalier Universitaire de Brest, Brest, France (G. Nevez, R. Le Berre); Université Paris 13, Paris (S. Brun); Université de Paris, Paris (M. Gits-Muselli, F. Lanternier, S. Bretagne)

Main Article

Figure 2

Maximum-likelihood tree obtained from combined large subunit ribosomal DNA, actin, and internal transcribed spacer 2 sequence data obtained from genomic analysis of Nannizziopsis obscura isolates from 9 patients from West Africa, France, 2004–2020, and reference sequences. Neighbor-joining bootstrap values or maximum-likelihood values are indicated on the branches. Support branch values <70% are not shown. Culture collection numbers appear next to sequences retrieved from GenBank, and type st

Figure 2. Maximum-likelihood tree obtained from combined large subunit ribosomal DNA, actin, and internal transcribed spacer 2 sequence data obtained from genomic analysis of Nannizziopsis obscura isolates from 9 patients from West Africa, France, 2004–2020, and reference sequences. Neighbor-joining bootstrap values or maximum-likelihood values are indicated on the branches. Support branch values <70% are not shown. Culture collection numbers appear next to sequences retrieved from GenBank, and type strains are indicated by a T after the species name. Patients from whom clinical isolates analyzed in this study were obtained are shown as P1–P9. The 2 isolates from patient 8 were morphologically and molecularly identical. Sequences marked with asterisks (*) refer to strains published by Nourrisson et al. (6). Scale bar indicates nucleotide substitutions per character.

Main Article

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Main Article

1Preliminary results of this study were presented at the International Society for Human and Animal Mycology, June 30–July 4, 2018, Amsterdam, the Netherlands (poster 174, Medical Mycology 56, Supplement 2).

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