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Volume 27, Number 1—January 2021
Dispatch

Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

Clara Bergmann, Welmoed van LoonComments to Author , Felix Habarugira, Costanza Tacoli, Julia C. Jäger, Darius Savelsberg, Fabian Nshimiyimana, Elias Rwamugema, Djibril Mbarushimana, Jules Ndoli, Augustin Sendegeya, Claude Bayingana, and Frank P. Mockenhaupt
Author affiliations: Charité–Universitätsmedizin Berlin, Berlin, Germany (C. Bergmann, W. van Loon, C. Tacoli, J.C. Jäger, D. Savelsberg, F.P. Mockenhaupt); University Teaching Hospital of Butare, Butare, Rwanda (F. Habarugira, E. Rwamugema, D. Mbarushimana, J. Ndoli, A. Sendegeya); Kabutare District Hospital, Butare (F. Nshimiyimana); University of Rwanda, Kigali, Rwanda (C. Bayingana)

Main Article

Table

Nonsynonymous single nucleotide polymorphisms in the Kelch 13 propeller domain of clinical Plasmodium falciparum isolates collected in the Huye District, Rwanda, 2010–2019*

Year No. sequenced isolates No. (%) isolates with nonsynonymous mutations Amino acid changes and nucleotide changes
2010 75 0 Not applicable
2014 81 2 (2.5) V555A, A626S
2015 66 3 (4.5) P574L,† D648H, A675V†
2019 66 8 (12.1) C469F,† G533A, V555A, R561H‡ (3×), A578S, A675V†

*Data during 2010–2015 derived from Tacoli et al. (7). 
†Candidate mutations for artemisinin resistance. 
‡Validated mutation for artemisinin resistance (4).

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