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Volume 27, Number 11—November 2021
Dispatch

Acute Chagas Disease Manifesting as Orbital Cellulitis, Texas, USA

F. Parker HudsonComments to Author , Natalie Homer, Aliza Epstein, and Kristin Mondy
Author affiliations: University of Texas Austin Dell Medical School, Austin, Texas, USA (F.P. Hudson, K. Mondy); Texas Oculoplastics Consultants, Austin (N. Homer, A. Epstein)

Main Article

Figure 2

Results of next-generation sequencing on a plasma sample of a patient with acute Chagas disease manifesting as orbital cellulitis, Texas, USA, showing the very high detection of Trypanosoma cruzi (505.61 MPM) (right). The comparison with 1,000 aggregated negative controls (buffer/reagents) show a very low microbial cell-free DNA (mcfDNA) signal, which aligned to T. cruzi in 1 sample (left). A cohort of 684 healthy controls had a very low mcfDNA signal, which aligned to T. cruzi in 1 person (middle). The purple dots indicate any mcfDNA that align to T. cruzi; the gold star indicates an mcfDNA detection that represents a positive result for T. cruzi identified by the Karius Test (Karius, Inc., https://kariusdx.com). The other detected but not clinically or statistically significant mcfDNA in the case patient’s sample are also shown in the gray box and whisker plot on the log scale; horizontal line within box indicates median, box top and bottom indicate interquartile range (Q1–Q3), and error bars indicate range. MPM, molecules/μL.

Figure 2. Results of next-generation sequencing on a plasma sample of a patient with acute Chagas disease manifesting as orbital cellulitis, Texas, USA, showing the very high detection of Trypanosoma cruzi (505.61 MPM) (right). The comparison with 1,000 aggregated negative controls (buffer/reagents) show a very low microbial cell-free DNA (mcfDNA) signal, which aligned to T. cruzi in 1 sample (left). A cohort of 684 healthy controls had a very low mcfDNA signal, which aligned to T. cruzi in 1 person (middle). The purple dots indicate any mcfDNA that align to T. cruzi; the gold star indicates an mcfDNA detection that represents a positive result for T. cruzi identified by the Karius Test (Karius, Inc., https://kariusdx.com). The other detected but not clinically or statistically significant mcfDNA in the case patient’s sample are also shown in the gray box and whisker plot on the log scale; horizontal line within box indicates median, box top and bottom indicate interquartile range (Q1–Q3), and error bars indicate range. MPM, molecules/μL.

Main Article

Page created: October 13, 2021
Page updated: October 19, 2021
Page reviewed: October 19, 2021
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