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Volume 27, Number 11—November 2021
Dispatch

Emergence of Vibrio cholerae O1 Sequence Type 75, South Africa, 2018–2020

Anthony M. SmithComments to Author , François-Xavier Weill, Elisabeth Njamkepo, Hlengiwe M. Ngomane, Ntsieni Ramalwa, Phuti Sekwadi, and Juno Thomas
Author affiliations: National Institute for Communicable Diseases, Johannesburg, South Africa (A.M. Smith, H.M. Ngomane, N. Ramalwa, P. Sekwadi, J. Thomas); University of Pretoria, Pretoria, South Africa (A.M. Smith, N. Ramalwa); Institut Pasteur, Paris, France (F.-X. Weill, E. Njamkepo)

Main Article

Table 2

Features of Vibrio cholerae O1 ST75 isolates, South Africa, 2018–2020*

Strain no. Serotype Biotype AMR phenotype AMR gene Plasmids ctxB allele tcpA wbeT mutation† Lineage‡
YA00085869 Ogawa El Tor Pansusceptible qnrVC4 None ctxB1 tcpAN16961 WT L3b.1
YA00132994 Inaba El Tor Pansusceptible qnrVC4 None ctxB1 tcpAN16961 B08 L3b.1
YA00134463 Inaba El Tor Pansusceptible qnrVC4 None ctxB1 tcpAN16961 B08 L3b.1
OA01603367 Inaba El Tor Pansusceptible qnrVC4 None ctxB1 tcpAN16961 B08 L3b.1
YA00192016 Ogawa El Tor Pansusceptible qnrVC4 None ctxB1 tcpAN16961 WT L3b.1
CF00214281 Ogawa El Tor Pansusceptible qnrVC4 None ctxB1 tcpAN16961 WT L3b.1
YA00193061 Ogawa El Tor Pansusceptible qnrVC4 None ctxB1 tcpAN16961 WT L3b.1

*AMR, antimicrobial resistance; ST, sequence type; WT, wild-type. †Nomenclature according to F.-X. Weill et al. (5). ‡Nomenclature according to H. Wang et al. (9).

Main Article

References
  1. Mintz  ED, Tauxe  RV. Cholera in Africa: a closer look and a time for action. J Infect Dis. 2013;208(Suppl 1):S4–7. DOIPubMedGoogle Scholar
  2. Küstner  HG, Gibson  IH, Carmichael  TR, Van Zyl  L, Chouler  CA, Hyde  JP, et al. The spread of cholera in South Africa. S Afr Med J. 1981;60:87–90.PubMedGoogle Scholar
  3. Ismail  H, Smith  AM, Tau  NP, Sooka  A, Keddy  KH; Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa. Cholera outbreak in South Africa, 2008-2009: laboratory analysis of Vibrio cholerae O1 strains. J Infect Dis. 2013;208(Suppl 1):S39–45. DOIPubMedGoogle Scholar
  4. Mutreja  A, Kim  DW, Thomson  NR, Connor  TR, Lee  JH, Kariuki  S, et al. Evidence for several waves of global transmission in the seventh cholera pandemic. Nature. 2011;477:462–5. DOIPubMedGoogle Scholar
  5. Weill  FX, Domman  D, Njamkepo  E, Tarr  C, Rauzier  J, Fawal  N, et al. Genomic history of the seventh pandemic of cholera in Africa. Science. 2017;358:785–9. DOIPubMedGoogle Scholar
  6. Ramamurthy  T, Mutreja  A, Weill  FX, Das  B, Ghosh  A, Nair  GB. Revisiting the global epidemiology of cholera in conjunction with the genomics of Vibrio cholerae. Front Public Health. 2019;7:237. DOIPubMedGoogle Scholar
  7. Irenge  LM, Ambroise  J, Mitangala  PN, Bearzatto  B, Kabangwa  RKS, Durant  JF, et al. Genomic analysis of pathogenic isolates of Vibrio cholerae from eastern Democratic Republic of the Congo (2014-2017). PLoS Negl Trop Dis. 2020;14:e0007642. DOIPubMedGoogle Scholar
  8. Mashe  T, Domman  D, Tarupiwa  A, Manangazira  P, Phiri  I, Masunda  K, et al. Highly resistant cholera outbreak strain in Zimbabwe. N Engl J Med. 2020;383:687–9. DOIPubMedGoogle Scholar
  9. Wang  H, Yang  C, Sun  Z, Zheng  W, Zhang  W, Yu  H, et al. Genomic epidemiology of Vibrio cholerae reveals the regional and global spread of two epidemic non-toxigenic lineages. PLoS Negl Trop Dis. 2020;14:e0008046. DOIPubMedGoogle Scholar
  10. Fonseca  EL, Dos Santos Freitas  F, Vieira  VV, Vicente  ACP. New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1. Emerg Infect Dis. 2008;14:1129–31. DOIPubMedGoogle Scholar
  11. Fonseca  EL, Vicente  ACP. Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family. J Med Microbiol. 2013;62:1628–30. DOIPubMedGoogle Scholar
  12. Tu  YH, Chen  BH, Hong  YP, Liao  YS, Chen  YS, Liu  YY, et al. Emergence of Vibrio cholerae O1 sequence type 75 in Taiwan. Emerg Infect Dis. 2020;26:164–6. DOIPubMedGoogle Scholar
  13. Luo  Y, Octavia  S, Jin  D, Ye  J, Miao  Z, Jiang  T, et al. US Gulf-like toxigenic O1 Vibrio cholerae causing sporadic cholera outbreaks in China. J Infect. 2016;72:564–72. DOIPubMedGoogle Scholar
  14. Wachsmuth  IK, Bopp  CA, Fields  PI, Carrillo  C. Difference between toxigenic Vibrio cholerae O1 from South America and US gulf coast. Lancet. 1991;337:1097–8. DOIPubMedGoogle Scholar
  15. Domman  D, Quilici  ML, Dorman  MJ, Njamkepo  E, Mutreja  A, Mather  AE, et al. Integrated view of Vibrio cholerae in the Americas. Science. 2017;358:789–93. DOIPubMedGoogle Scholar

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Page created: September 10, 2021
Page updated: October 19, 2021
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