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Volume 27, Number 11—November 2021
Dispatch

Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis1

Nico A.F. Janssen, Rémy Nyga, Lore Vanderbeke, Cato Jacobs, Mehmet Ergün, Jochem B. Buil, Karin van Dijk, Josje Altenburg, Catherine S.C. Bouman, Hans I. van der Spoel, Bart J.A. Rijnders, Albert Dunbar, Jeroen A. Schouten, Katrien Lagrou, Marc Bourgeois, Marijke Reynders, Niels van Regenmortel, Lynn Rutsaert, Piet Lormans, Simon Feys, Yves Debavaye, Fabienne Tamion, Damien Costa, Julien Maizel, Hervé Dupont, Taieb Chouaki, Saad Nseir, Boualem Sendid, Roger J.M. Brüggemann, Frank L. van de Veerdonk, Joost Wauters2, and Paul E. Verweij2Comments to Author 
Author affiliations: Radboud University Medical Center, Nijmegen, the Netherlands (N.A.F Janssen, M. Ergün, J.B. Buil, J.A. Schouten, R.J.M. Brüggemann, F.L. van de Veerdonk, P.E. Verweij); Amiens University Hospital, Amiens, France (R. Nyga, J. Maizel, H. Dupont, T. Chouaki); University Hospitals Leuven, Leuven, Belgium (L. Vanderbeke, C. Jacobs, K. Lagrou, Y. Debavaye, J. Wauters); Katholieke Universiteit Leuven, Leuven (L. Vanderbeke, K. Lagrou, J. Wauters); Amsterdam University Medical Centers, Amsterdam, the Netherlands (K. van Dijk, J. Altenburg, C.S.C. Bouman, H. van der Spoel); Erasmus Medical Center, Rotterdam, the Netherlands (B.J.A. Rijnders, A. Dunbar); AZ Sint-Jan Brugge-Oostende, Brugge, Belgium (M. Bourgeois, M. Reynders); ZNA Campus Stuivenberg, Antwerpen, Belgium (N. van Regenmortel, L. Rutsaert); AZ Delta Hospital, Roeselare, Belgium (P. Lormans, S. Feys); Rouen University Hospital, Rouen, France (F. Tamion, D. Costa); Lille University Hospital, Lille, France (S. Nseir, B. Sendid); University of Lille, Lille (S. Nseir, B. Sendid)

Main Article

Figure 1

Flowchart of the study inclusion process for a multinational observational study of CAPA in 3 countries in Europe, 2020. A) Discovery cohort; B) validation cohort. For further analyses, patients with proven, probable, and possible CAPA were designated to the CAPA group. Patients were classified to the CAPA excluded group when they had >1 negative mycological test according to 2020 ECMM/ISHAM classification consensus criteria (11). Patients who did not undergo any of the mycological tests were designated to the CAPA not classifiable group. *Value includes 6 patients in whom CAPA was excluded at the time of autopsy. CAPA, COVID-19–associated pulmonary aspergillosis; COVID-19, coronavirus disease; ECMM/ISHAM, European Confederation for Medical Mycology/International Society for Human and Animal Mycology; ICU, intensive care unit.

Figure 1. Flowchart of the study inclusion process for a multinational observational study of CAPA in 3 countries in Europe, 2020. A) Discovery cohort; B) validation cohort. For further analyses, patients with proven, probable, and possible CAPA were designated to the CAPA group. Patients were classified to the CAPA excluded group when they had >1 negative mycological test according to 2020 ECMM/ISHAM classification consensus criteria (11). Patients who did not undergo any of the mycological tests were designated to the CAPA not classifiable group. *Value includes 6 patients in whom CAPA was excluded at the time of autopsy. CAPA, COVID-19–associated pulmonary aspergillosis; COVID-19, coronavirus disease; ECMM/ISHAM, European Confederation for Medical Mycology/International Society for Human and Animal Mycology; ICU, intensive care unit.

Main Article

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Main Article

1The results of this study were presented at the Scientific Spring Meeting of the Dutch Society of Medical Microbiology (NVMM) and the Royal Dutch Society of Microbiology (KNVM), held online March 30–31, 2021; and at the 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), held online from July 9–12, 2021.

2These authors were co–principal investigators.

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