Mutations Associated with SARS-CoV-2 Variants of Concern, Benin, Early 2021
Anna-Lena Sander
1, Anges Yadouleton
1, Edmilson F. de Oliveira Filho, Carine Tchibozo, Gildas Hounkanrin, Yvette Badou, Praise Adewumi, Keke K. René, Dossou Ange, Salifou Sourakatou, Eclou Sedjro, Melchior A. J. Aïssi, Hinson Fidelia, Mamoudou Harouna Djingarey, Michael Nagel, Wendy Karen Jo, Andres Moreira-Soto, Christian Drosten, Olfert Landt, Victor Max Corman, Benjamin Hounkpatin, and Jan Felix Drexler
Author affiliations: Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Virology, Berlin, Germany (A.-L. Sander, E.F. de Oliveira Filho, W.K. Jo, A. Moreira-Soto, C. Drosten, V.M. Corman, J.F. Drexler); Ecole Normale Supérieure de Natitingou, Natitingou, Benin (A. Yadouleton); Université Nationale des Sciences, Technologies, Ingénierie et Mathématiques (UNSTIM), Cotonou, Benin (A. Yadouleton); Laboratoire des Fièvres Hémorragiques Virales du Benin, Cotonou (A. Yadouleton, C. Tchibozo, G. Hounkanrin, Y. Badou, P. Adewumi); Ministry of Health, Cotonou (K.K. René, D. Ange, S. Sourakatou, B. Hounkpatin); Conseil National de Lutte contre le VIH-Sida, la Tuberculose, le Paludisme, les IST et les Epidémies, Cotonou (E. Sedjro, M.A. Joël Aïssi, H. Fidelia); World Health Organization Regional Office for Africa, Health Emergencies Programme, Brazzaville, Democratic Republic of the Congo (M.H. Djingarey); Deutsche Gesellschaft für Internationale Zusammenarbeit, Bonn, Germany (M. Nagel); German Centre for Infection Research (DZIF), associated partner Charité-Universitätsmedizin Berlin, Berlin (C. Drosten, V.M. Corman, J.F. Drexler); TIB Molbiol Syntheselabor GmbH, Berlin (O. Landt)
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Figure 2
![PRNT results of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants from Benin, 2021. Graphs compare results of neutralization tests for naturally infected persons (A) and persons who received the Pfizer-BioNTech vaccine (BNT162b2; https://www.pfizer.com) (B) against the B.1.153 lineage from January 2020 (Munich/ChVir929/2020 strain; GISAID [http://www.gisaid.org] accession no. EPI_ISL_406862; Pangolin version 2021–05–19), the Beta stain (Baden-Wuertemberg/ChVir22131/2021; accession no. EPI_ISL_862149; B.1.351; Pangolin version 2021–05–19) and the B.1.1.7, B.1.214.2, B.1, and A.27 lineages isolated from patients from Benin. Lines denote the mean PRNT50 endpoint titer. Statistical significance was determined by the Dunn’s multiple comparisons test. Nonsignificant values are not shown for clarity of presentation. PRNT50, 50% plaque reduction neutralization test.](/eid/images/21-1353-F2.jpg)
Figure 2. PRNT results of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants from Benin, 2021. Graphs compare results of neutralization tests for naturally infected persons (A) and persons who received the Pfizer-BioNTech vaccine (BNT162b2; https://www.pfizer.com) (B) against the B.1.153 lineage from January 2020 (Munich/ChVir929/2020 strain; GISAID [http://www.gisaid.org] accession no. EPI_ISL_406862; Pangolin version 2021–05–19), the Beta stain (Baden-Wuertemberg/ChVir22131/2021; accession no. EPI_ISL_862149; B.1.351; Pangolin version 2021–05–19) and the B.1.1.7, B.1.214.2, B.1, and A.27 lineages isolated from patients from Benin. Lines denote the mean PRNT50 endpoint titer. Statistical significance was determined by the Dunn’s multiple comparisons test. Nonsignificant values are not shown for clarity of presentation. PRNT50, 50% plaque reduction neutralization test.
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