Skip directly to page options Skip directly to A-Z link
Volume 27, Number 2—February 2021
Research

Prolonged Maternal Zika Viremia as a Marker of Adverse Perinatal Outcomes

Léo Pomar, Véronique Lambert, Séverine Matheus, Céline Pomar, Najeh Hcini, Gabriel Carles, Dominique Rousset, Manon Vouga, Alice Panchaud1, and David Baud1Comments to Author 
Author affiliations: Lausanne University Hospital, Lausanne, Switzerland (L. Pomar, C. Pomar, M. Vouga, A. Panchaud, D. Baud); Centre Hospitalier de l’Ouest Guyanais Franck Joly, Saint-Laurent-du-Maroni, French Guiana (V. Lambert, C. Pomar, N. Hcini, G. Carles); Institut Pasteur, Paris, France (S. Matheus); Institut Pasteur of French Guiana, Cayenne, French Guiana (S. Matheus, D. Rousset); University of Bern, Bern, Switzerland (A. Panchaud)

Main Article

Figure 2

Pregnancy outcomes of patients with prolonged viremia in a cohort study of pregnant women admitted to Centre Hospitalier de l’Ouest Guyanais, French Guiana, January 1–July 15, 2016. Description and outcomes of 14 pregnancies with prolonged maternal ZIKV viremia (including 1 with dichorionic twin pregnancy). Congenital ZIKV infection was confirmed in 9/15 (60%) fetuses, and 6/15 (40%) fetuses had adverse outcomes. Four of them had multiple abnormalities consistent with CZS (1 live birth, 1 TOP, 1 IUFD, and 1 stillbirth). The 2 fetuses from the dichorionic twin pregnancy also had adverse outcomes, with an IUFD at 24 wk and a TOP for severe ventriculomegaly in the other fetus at 29 wk. CSF, cerebrospinal fluid; CZS, congenital Zika syndrome; HC, head circumference; IUFD, intrauterine fetal demise; RT-PCR, reverse transcription PCR; TOP, termination of pregnancy; ZIKV, Zika virus.

Figure 2. Pregnancy outcomes of patients with prolonged viremia in a cohort study of pregnant women admitted to Centre Hospitalier de l’Ouest Guyanais, French Guiana, January 1–July 15, 2016. Description and outcomes of 14 pregnancies with prolonged maternal ZIKV viremia (including 1 with dichorionic twin pregnancy). Congenital ZIKV infection was confirmed in 9/15 (60%) fetuses, and 6/15 (40%) fetuses had adverse outcomes. Four of them had multiple abnormalities consistent with CZS (1 live birth, 1 TOP, 1 IUFD, and 1 stillbirth). The 2 fetuses from the dichorionic twin pregnancy also had adverse outcomes, with an IUFD at 24 wk and a TOP for severe ventriculomegaly in the other fetus at 29 wk. CSF, cerebrospinal fluid; CZS, congenital Zika syndrome; HC, head circumference; IUFD, intrauterine fetal demise; RT-PCR, reverse transcription PCR; TOP, termination of pregnancy; ZIKV, Zika virus.

Download

Main Article

1These senior authors contributed equally to this article.

Page created: December 10, 2020
Page updated: January 23, 2021
Page reviewed: January 23, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external