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Volume 27, Number 2—February 2021
Research Letter

Potential Association between Zika Infection and Microcephaly during 2007 Fever Outbreak, Gabon

Claudine A. Kombila Koumavor, Eric Elguero, and Eric M. LeroyComments to Author 
Author affiliations: University of Health Sciences, Libreville, Gabon (C.A. Kombila Koumavor); Institute for Sustainable Development, IRD-CNRS-University of Montpellier Unit, Montpellier, France (E. Elguero, E. Leroy)

Main Article

Figure

Cases of microcephaly (A) and limb malformations (B) in Libreville, Gabon, during January 2006–December 2008. Histograms correspond to the total number of births over the time of the study period. Scales for the y-axes differ to underscore patterns but do not permit direct comparisons. Green boxes encompass the time period when the febrile illness outbreak happened; purple boxes encompass the time period of births of infants whose mothers could have been exposed to Zika in their first trimester of pregnancy during the outbreak. Numbers of births were collected from birth registers by 2-month periods from January–February 2006 through November–December 2008. (Births are recorded in the registers in such a way that we were unable to obtain data for single months.) The duration of the febrile illness outbreak was estimated by the Health Ministry of Gabon during April 2007–August 2007, based on information communicated by hospitals. The febrile illness outbreak coincided with an increase in the number of patients seeking treatment for painful febrile illnesses at healthcare centers beginning in April 2007. The end of the outbreak in August 2017 coincided with the disappearance for >15 days of grouped clinical cases and with negative test results from samples.

Figure. Cases of microcephaly (A) and limb malformations (B) in Libreville, Gabon, during January 2006–December 2008. Histograms correspond to the total number of births over the time of the study period. Scales for the y-axes differ to underscore patterns but do not permit direct comparisons. Green boxes encompass the time period when the febrile illness outbreak happened; purple boxes encompass the time period of births of infants whose mothers could have been exposed to Zika in their first trimester of pregnancy during the outbreak. Numbers of births were collected from birth registers by 2-month periods from January–February 2006 through November–December 2008. (Births are recorded in the registers in such a way that we were unable to obtain data for single months.) The duration of the febrile illness outbreak was estimated by the Health Ministry of Gabon during April 2007–August 2007, based on information communicated by hospitals. The febrile illness outbreak coincided with an increase in the number of patients seeking treatment for painful febrile illnesses at healthcare centers beginning in April 2007. The end of the outbreak in August 2017 coincided with the disappearance for >15 days of grouped clinical cases and with negative test results from samples.

Main Article

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