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Volume 27, Number 4—April 2021
Dispatch

Fatal Case of Crimean-Congo Hemorrhagic Fever Caused by Reassortant Virus, Spain, 2018

Anabel NegredoComments to Author , Rafael Sánchez-Arroyo, Francisco Díez-Fuertes, Fernando de Ory, Marco Antonio Budiño, Ana Vázquez, Ángeles Garcinuño, Lourdes Hernández, César de la Hoz González, Almudena Gutiérrez-Arroyo, Carmen Grande, and Paz Sánchez-Seco
Author affiliations: National Center of Microbiology, Madrid, Spain (A. Negredo, F. Díez-Fuertes, F. De Ory, A. Vázquez, L. Hernández, P. Sánchez-Seco); Complejo Asistencial de Ávila, Ávila, Spain (R. Sánchez-Arroyo, M.A. Budiño, A. Garcinuño, C. de la Hoz González, C. Grande); CIBERESP, Madrid (A. Vázquez); La Paz Hospital, Madrid (A. Gutiérrez-Arroyo)

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Figure 2

Bayesian phylogenetic trees showing genetic relationships among Crimean-Congo hemorrhagic fever (CCHFV) viruses based on complete small (A), medium (B), and large (C) segment sequences. In the medium segment, the hypervariable mucin-like domain was excluded. We used CIPRES Science gateway (http://www.phylo.org) to implement Bayesian analyses. Black dots indicate nodes with posterior probabilities >0.95; boldface indicates CCHFV strain Badajoz 2018 from Spain; arrowheads indicate other isolates from Spain. Other sequences are named by GenBank accession number, strain, geographic origin, and sampling year. Sequences from this study are included in EMBL/GenBank databases. Roman numerals indicate genotypes, named according to (4) with the equivalent clade nomenclature according to (5) indicated by brackets: I, West Africa (Africa 1); II, Central Africa (Africa 2); III, South and West Africa (Africa 3); IV, Middle East/Asia, divided in 2 groups corresponding to groups Asia 1 and Asia 2; V, Europe/Turkey (Europe 1); VI, Greece (Europe 2). Italics indicate the proposed new lineage, Africa 4. Scale bars indicate time in years.

Figure 2. Bayesian phylogenetic trees showing genetic relationships among Crimean-Congo hemorrhagic fever (CCHFV) viruses based on complete small (A), medium (B), and large (C) segment sequences. In the medium segment, the hypervariable mucin-like domain was excluded. We used CIPRES Science gateway (http://www.phylo.org) to implement Bayesian analyses. Black dots indicate nodes with posterior probabilities >0.95; boldface indicates CCHFV strain Badajoz 2018 from Spain; arrowheads indicate other isolates from Spain. Other sequences are named by GenBank accession number, strain, geographic origin, and sampling year. Sequences from this study are included in EMBL/GenBank databases. Roman numerals indicate genotypes, named according to (4) with the equivalent clade nomenclature according to (5) indicated by brackets: I, West Africa (Africa 1); II, Central Africa (Africa 2); III, South and West Africa (Africa 3); IV, Middle East/Asia, divided in 2 groups corresponding to groups Asia 1 and Asia 2; V, Europe/Turkey (Europe 1); VI, Greece (Europe 2). Italics indicate the proposed new lineage, Africa 4. Scale bars indicate time in years.

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References
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