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Volume 27, Number 4—April 2021
Research Letter

Co-infection with Severe Fever with Thrombocytopenia Syndrome Virus and Rickettsia japonica after Tick Bite, Japan

Tatsuya FujikawaComments to Author , Tomoki Yoshikawa, Takeshi Kurosu, Masayuki Shimojima, Masayuki Saijo, and Kyoko Yokota
Author affiliations: Mitoyo General Hospital, Kanonji, Japan (T. Fujikawa); National Institute of Infectious Diseases, Tokyo, Japan (T. Yoshikawa, T. Kurosu, M. Shimojima, M. Saijo); Kagawa Prefectural Central Hospital, Takamatsu, Japan (K. Yokota)

Main Article


Laboratory findings in patient with severe fever with thrombocytopenia syndrome and positive Rickettsia japonica DNA in eschar at site of tick bite, Japan*

Parameter Values Reference range
Total blood cell counts
Leukocytes 17.1 × 102/µL 33–86 × 102/μL
Erythrocytes 410 × 104/µL 380–500 × 104/µL
Hemoglobin 12.4 g/dL 11.5–15.0 g/dL
Hematocrit 35.2% 35.0%–45.0%
Platelets 7.4 × 104/µL 15–35 × 104/μL
Coagulation-associated tests
PT 10.3 s 9.9–11.8 s
APTT 45.9 s 23.0–39.0 s
FDP 4.3 µg/mL 0.0–5.0 µg/mL
1.2 µg/mL
0.0–1.0 µg/mL
Serum chemistry
CRP <1.0 mg/dL 0.00–0.14 mg/dL
AST 42 U/L 13–30 U/L
ALT 18 U/L 7–23 U/L
ALP 170 U/L 106–322 U/L
γ-GT 14 U/L 9–32 U/L
Total bilirubin 0.5 mg/dL 0.4–1.5 mg/dL
LDH 200 U/L 124–222 U/L
CK 63 U/L 59–248 U/L
Total protein 7.1 g/dL 6.6–8.1 g/dL
Albumin 3.9 g/dL 4.1–5.1 g/dL
BUN 26 mg/dL 8–20 mg/dL
Creatinine 0.76 mg/dL 0.46–0.79 mg/dL
eGFR 54.5 mL/min 80–100 mL/min
Ccr 41.8 mL/min NA
Uric acid 3.7 mg/dL 2.6–5.5 mg/dL
Sodium 127 mmol/L 138–145 mmol/L
Potassium 3.8 mmol/L 3.6–4.8 mmol/L
Chloride 92 mmol/L 101–108 mmol/L

*ALP, alkaline phosphatase; ALT, alanine transaminase; APTT, activated partial thromboplastin time; AST, aspartate transaminase; BUN, blood urea nitrogen; Ccr, calculated creatinine clearance; CK, creatine kinase; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; FDP, fibrin/fibrinogen degradation products; LDH, lactate dehydrogenase; PT, prothrombin time; SFTS, severe fever with thrombocytopenia syndrome; γ-GT, γ-glutamyl transpeptidase.

Main Article

Page created: March 09, 2021
Page updated: March 19, 2021
Page reviewed: March 19, 2021
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