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Volume 27, Number 6—June 2021
Research Letter

Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020

Mariene R. Amorim1, William M. Souza1, Antonio C.G. Barros, Daniel A. Toledo-Teixeira, Karina Bispo dos-Santos, Camila L. Simeoni, Pierina L. Parise, Aline Vieira, Julia Forato, Ingra M. Claro, Luciana S. Mofatto, Priscila P. Barbosa, Natalia S. Brunetti, Emerson S.S. França, Gisele A. Pedroso, Barbara F.N. Carvalho, Tania R. Zaccariotto, Kamila C.S. Krywacz, André S. Vieira, Marcelo A. Mori, Alessandro S. Farias, Maria H.P. Pavan, Luís Felipe Bachur, Luís G.O. Cardoso, Fernando R. Spilki, Ester C. Sabino, Nuno R. Faria, Magnun N.N. Santos, Rodrigo Angerami, Patricia A.F. Leme, Angelica Schreiber, Maria L. Moretti, Fabiana GranjaComments to Author , and José Luiz Proenca-Modena
Author affiliations: University of Campinas, Campinas, Brazil (M.R. Amorim, A.C.G. Barros Jr., D.A. Toledo-Teixeira, K. Bispo-dos-Santos, C.L. Simeoni, P.L. Parise, A. Vieira, J. Forato, L.S. Mofatto, P.P. Barbosa, N.S. Brunetti, E.S.S. França, G.A. Pedroso, B.F.N. Carvalho, T.R. Zaccariotto, K.C.S. Krywacz, A.S. Vieira, M.A. Mori, A.S. Farias, M.H.P. Pavan, L.F. Bachur, L.G.O. Cardoso, M.N.N. Santos, R. Angerami, P.A.F. Leme, A. Schreiber, M.L. Moretti, F. Granja, J.L. Proenca-Modena); University of São Paulo, São Paulo, Brazil (W.M. Souza, I.M. Claro, E.C. Sabino, N.R. Faria); Feevale University, Novo Hamburgo, Brazil (F.R. Spilki); University of Oxford, Oxford, UK (N.R. Faria); Imperial College London, London, UK (N.R. Faria); Campinas Department of Public Health Surveillance, Campinas (R. Angerami); Federal University of Roraima, Boa Vista, Brazil (F. Granja)

Main Article


Characteristics of healthcare workers with severe acute respiratory syndrome coronavirus 2 reinfections, Brazil, 2020*

Characteristic Healthcare worker
1 2 3 4
Underlying conditions
Chronic bronchitis
First infection Fever, headache, chills, sneezing, coryza, and myalgia Headache, cough, myalgia, odynophagy, coryza, diarrhea, and ageusia Nasal congestion, coryza, cough, ageusia Fever, headache, myalgia, coryza, dry cough, vomiting, and malaise
Second infection
Headache, nasal congestion, odynophagia, ageusia, and anosmia
Cough, myalgia, odynophagia, anosmia, and diarrhea
Odynophagia, sneezing, coryza, diarrhea, ageusia, and anosmia
Odynophagia, dry cough, myalgia, malaise, coryza, and headache
Cycle threshold values
First infection† E gene: 35.24; N gene: 40.12 E gene: 31.8 E gene: 35.15 E gene: 34.80; RdRp gene: 39.86
Second infection‡
E gene: 31.14; N gene: 31.3; RdRp gene: 32.58
E gene: 20.45; N gene: 20.52; RdRp gene: 22.65
E gene: 26.04; N gene: 26.88; RdRp gene: 28.40
E gene: 23.72; N gene: 23.48; RdRp gene: 25.67
Time between symptom onsets, d 55 170 131 148

*E gene, envelope gene; N gene, nucleoprotein gene; RdRp gene, RNA dependent RNA polymerase gene.
†Real-time quantitative reverse transcription PCR selective for the envelope gene (2).
‡Nucleic acid amplification test using the GeneFinder COVID-19 Plus RealAmp Kit (OSANG Healthcare Co. Ltd., (3).

Main Article

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Main Article

1These authors contributed equally to this article.

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